Optimization of Solid-Supported Glaser-Hay Reactions in the Microwave

The translation of organometallic reactions into a microwave reactor has numerous advantages. Herein, we describe the application of a previously developed solid-supported Glaser-Hay reaction to microwave conditions. Overall, an array of diynes has been prepared demonstrating the ability to conduct...

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Detalles Bibliográficos
Autores principales: Lampkowski, Jessica S., Maza, Johnathan C., Verma, Sanjana, Young, Douglas D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272721/
https://www.ncbi.nlm.nih.gov/pubmed/25812149
http://dx.doi.org/10.3390/molecules20045276
Descripción
Sumario:The translation of organometallic reactions into a microwave reactor has numerous advantages. Herein, we describe the application of a previously developed solid-supported Glaser-Hay reaction to microwave conditions. Overall, an array of diynes has been prepared demonstrating the ability to conduct chemoselective reactions in the microwave within 20 min compared to the 16 h thermal conditions. Moreover, non-microwave transparent alkynes have been found to react more quickly, preventing catalyst quenching, and resulting in higher yields.

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