Optimization of Solid-Supported Glaser-Hay Reactions in the Microwave

The translation of organometallic reactions into a microwave reactor has numerous advantages. Herein, we describe the application of a previously developed solid-supported Glaser-Hay reaction to microwave conditions. Overall, an array of diynes has been prepared demonstrating the ability to conduct...

Descripción completa

Detalles Bibliográficos
Autores principales: Lampkowski, Jessica S., Maza, Johnathan C., Verma, Sanjana, Young, Douglas D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272721/
https://www.ncbi.nlm.nih.gov/pubmed/25812149
http://dx.doi.org/10.3390/molecules20045276
_version_ 1783377222777700352
author Lampkowski, Jessica S.
Maza, Johnathan C.
Verma, Sanjana
Young, Douglas D.
author_facet Lampkowski, Jessica S.
Maza, Johnathan C.
Verma, Sanjana
Young, Douglas D.
author_sort Lampkowski, Jessica S.
collection PubMed
description The translation of organometallic reactions into a microwave reactor has numerous advantages. Herein, we describe the application of a previously developed solid-supported Glaser-Hay reaction to microwave conditions. Overall, an array of diynes has been prepared demonstrating the ability to conduct chemoselective reactions in the microwave within 20 min compared to the 16 h thermal conditions. Moreover, non-microwave transparent alkynes have been found to react more quickly, preventing catalyst quenching, and resulting in higher yields.
format Online
Article
Text
id pubmed-6272721
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62727212018-12-03 Optimization of Solid-Supported Glaser-Hay Reactions in the Microwave Lampkowski, Jessica S. Maza, Johnathan C. Verma, Sanjana Young, Douglas D. Molecules Communication The translation of organometallic reactions into a microwave reactor has numerous advantages. Herein, we describe the application of a previously developed solid-supported Glaser-Hay reaction to microwave conditions. Overall, an array of diynes has been prepared demonstrating the ability to conduct chemoselective reactions in the microwave within 20 min compared to the 16 h thermal conditions. Moreover, non-microwave transparent alkynes have been found to react more quickly, preventing catalyst quenching, and resulting in higher yields. MDPI 2015-03-24 /pmc/articles/PMC6272721/ /pubmed/25812149 http://dx.doi.org/10.3390/molecules20045276 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Lampkowski, Jessica S.
Maza, Johnathan C.
Verma, Sanjana
Young, Douglas D.
Optimization of Solid-Supported Glaser-Hay Reactions in the Microwave
title Optimization of Solid-Supported Glaser-Hay Reactions in the Microwave
title_full Optimization of Solid-Supported Glaser-Hay Reactions in the Microwave
title_fullStr Optimization of Solid-Supported Glaser-Hay Reactions in the Microwave
title_full_unstemmed Optimization of Solid-Supported Glaser-Hay Reactions in the Microwave
title_short Optimization of Solid-Supported Glaser-Hay Reactions in the Microwave
title_sort optimization of solid-supported glaser-hay reactions in the microwave
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272721/
https://www.ncbi.nlm.nih.gov/pubmed/25812149
http://dx.doi.org/10.3390/molecules20045276
work_keys_str_mv AT lampkowskijessicas optimizationofsolidsupportedglaserhayreactionsinthemicrowave
AT mazajohnathanc optimizationofsolidsupportedglaserhayreactionsinthemicrowave
AT vermasanjana optimizationofsolidsupportedglaserhayreactionsinthemicrowave
AT youngdouglasd optimizationofsolidsupportedglaserhayreactionsinthemicrowave

Ejemplares similares