Synthesis and Antimicrobial Activity of N-Substituted-β-amino Acid Derivatives Containing 2-Hydroxyphenyl, Benzo[b]phenoxazine and Quinoxaline Moieties

3-[(2-Hydroxyphenyl)amino]butanoic and 3-[(2-hydroxy-5-methyl(chloro)phenyl)amino]butanoic acids were converted to a series of derivatives containing hydrazide, pyrrole and chloroquinoxaline moieties. The corresponding benzo[b]phenoxazine derivatives were synthesized by the reaction of the obtained...

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Autores principales: Mickevičienė, Kristina, Baranauskaitė, Rūta, Kantminienė, Kristina, Stasevych, Maryna, Komarovska-Porokhnyavets, Olena, Novikov, Volodymyr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272739/
https://www.ncbi.nlm.nih.gov/pubmed/25689642
http://dx.doi.org/10.3390/molecules20023170
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author Mickevičienė, Kristina
Baranauskaitė, Rūta
Kantminienė, Kristina
Stasevych, Maryna
Komarovska-Porokhnyavets, Olena
Novikov, Volodymyr
author_facet Mickevičienė, Kristina
Baranauskaitė, Rūta
Kantminienė, Kristina
Stasevych, Maryna
Komarovska-Porokhnyavets, Olena
Novikov, Volodymyr
author_sort Mickevičienė, Kristina
collection PubMed
description 3-[(2-Hydroxyphenyl)amino]butanoic and 3-[(2-hydroxy-5-methyl(chloro)phenyl)amino]butanoic acids were converted to a series of derivatives containing hydrazide, pyrrole and chloroquinoxaline moieties. The corresponding benzo[b]phenoxazine derivatives were synthesized by the reaction of the obtained compounds with 2,3-dichloro-1,4-naphthoquinone. Five of the synthesized compounds exhibited good antimicrobial activity against Staphylococcus aureus and Mycobacterium luteum, whereas three compounds showed significant antifungal activity against Candida tenuis and Aspergillus niger.
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spelling pubmed-62727392018-12-13 Synthesis and Antimicrobial Activity of N-Substituted-β-amino Acid Derivatives Containing 2-Hydroxyphenyl, Benzo[b]phenoxazine and Quinoxaline Moieties Mickevičienė, Kristina Baranauskaitė, Rūta Kantminienė, Kristina Stasevych, Maryna Komarovska-Porokhnyavets, Olena Novikov, Volodymyr Molecules Article 3-[(2-Hydroxyphenyl)amino]butanoic and 3-[(2-hydroxy-5-methyl(chloro)phenyl)amino]butanoic acids were converted to a series of derivatives containing hydrazide, pyrrole and chloroquinoxaline moieties. The corresponding benzo[b]phenoxazine derivatives were synthesized by the reaction of the obtained compounds with 2,3-dichloro-1,4-naphthoquinone. Five of the synthesized compounds exhibited good antimicrobial activity against Staphylococcus aureus and Mycobacterium luteum, whereas three compounds showed significant antifungal activity against Candida tenuis and Aspergillus niger. MDPI 2015-02-13 /pmc/articles/PMC6272739/ /pubmed/25689642 http://dx.doi.org/10.3390/molecules20023170 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mickevičienė, Kristina
Baranauskaitė, Rūta
Kantminienė, Kristina
Stasevych, Maryna
Komarovska-Porokhnyavets, Olena
Novikov, Volodymyr
Synthesis and Antimicrobial Activity of N-Substituted-β-amino Acid Derivatives Containing 2-Hydroxyphenyl, Benzo[b]phenoxazine and Quinoxaline Moieties
title Synthesis and Antimicrobial Activity of N-Substituted-β-amino Acid Derivatives Containing 2-Hydroxyphenyl, Benzo[b]phenoxazine and Quinoxaline Moieties
title_full Synthesis and Antimicrobial Activity of N-Substituted-β-amino Acid Derivatives Containing 2-Hydroxyphenyl, Benzo[b]phenoxazine and Quinoxaline Moieties
title_fullStr Synthesis and Antimicrobial Activity of N-Substituted-β-amino Acid Derivatives Containing 2-Hydroxyphenyl, Benzo[b]phenoxazine and Quinoxaline Moieties
title_full_unstemmed Synthesis and Antimicrobial Activity of N-Substituted-β-amino Acid Derivatives Containing 2-Hydroxyphenyl, Benzo[b]phenoxazine and Quinoxaline Moieties
title_short Synthesis and Antimicrobial Activity of N-Substituted-β-amino Acid Derivatives Containing 2-Hydroxyphenyl, Benzo[b]phenoxazine and Quinoxaline Moieties
title_sort synthesis and antimicrobial activity of n-substituted-β-amino acid derivatives containing 2-hydroxyphenyl, benzo[b]phenoxazine and quinoxaline moieties
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272739/
https://www.ncbi.nlm.nih.gov/pubmed/25689642
http://dx.doi.org/10.3390/molecules20023170
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