Diterpenes Synthesized from the Natural Serrulatane Leubethanol and Their in Vitro Activities against Mycobacterium tuberculosis

Seventeen new derivatives of the natural diterpene leubethanol, including some potential pro-drugs, with changes in the functionality of the aliphatic chain or modifications of aromatic ring and the phenolic group, were synthesized and tested in vitro by the MABA technique for their activity against...

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Autores principales: Escarcena, Ricardo, Perez-Meseguer, Jonathan, del Olmo, Esther, Alanis-Garza, Blanca, Garza-González, Elvira, Salazar-Aranda, Ricardo, de Torres, Noemí Waksman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272751/
https://www.ncbi.nlm.nih.gov/pubmed/25905603
http://dx.doi.org/10.3390/molecules20047245
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author Escarcena, Ricardo
Perez-Meseguer, Jonathan
del Olmo, Esther
Alanis-Garza, Blanca
Garza-González, Elvira
Salazar-Aranda, Ricardo
de Torres, Noemí Waksman
author_facet Escarcena, Ricardo
Perez-Meseguer, Jonathan
del Olmo, Esther
Alanis-Garza, Blanca
Garza-González, Elvira
Salazar-Aranda, Ricardo
de Torres, Noemí Waksman
author_sort Escarcena, Ricardo
collection PubMed
description Seventeen new derivatives of the natural diterpene leubethanol, including some potential pro-drugs, with changes in the functionality of the aliphatic chain or modifications of aromatic ring and the phenolic group, were synthesized and tested in vitro by the MABA technique for their activity against the H37Rv strain of Mycobacterium tuberculosis. Some compounds showed antimycobacterial selectivity indices higher than leubethanol.
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spelling pubmed-62727512018-12-03 Diterpenes Synthesized from the Natural Serrulatane Leubethanol and Their in Vitro Activities against Mycobacterium tuberculosis Escarcena, Ricardo Perez-Meseguer, Jonathan del Olmo, Esther Alanis-Garza, Blanca Garza-González, Elvira Salazar-Aranda, Ricardo de Torres, Noemí Waksman Molecules Article Seventeen new derivatives of the natural diterpene leubethanol, including some potential pro-drugs, with changes in the functionality of the aliphatic chain or modifications of aromatic ring and the phenolic group, were synthesized and tested in vitro by the MABA technique for their activity against the H37Rv strain of Mycobacterium tuberculosis. Some compounds showed antimycobacterial selectivity indices higher than leubethanol. MDPI 2015-04-21 /pmc/articles/PMC6272751/ /pubmed/25905603 http://dx.doi.org/10.3390/molecules20047245 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Escarcena, Ricardo
Perez-Meseguer, Jonathan
del Olmo, Esther
Alanis-Garza, Blanca
Garza-González, Elvira
Salazar-Aranda, Ricardo
de Torres, Noemí Waksman
Diterpenes Synthesized from the Natural Serrulatane Leubethanol and Their in Vitro Activities against Mycobacterium tuberculosis
title Diterpenes Synthesized from the Natural Serrulatane Leubethanol and Their in Vitro Activities against Mycobacterium tuberculosis
title_full Diterpenes Synthesized from the Natural Serrulatane Leubethanol and Their in Vitro Activities against Mycobacterium tuberculosis
title_fullStr Diterpenes Synthesized from the Natural Serrulatane Leubethanol and Their in Vitro Activities against Mycobacterium tuberculosis
title_full_unstemmed Diterpenes Synthesized from the Natural Serrulatane Leubethanol and Their in Vitro Activities against Mycobacterium tuberculosis
title_short Diterpenes Synthesized from the Natural Serrulatane Leubethanol and Their in Vitro Activities against Mycobacterium tuberculosis
title_sort diterpenes synthesized from the natural serrulatane leubethanol and their in vitro activities against mycobacterium tuberculosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272751/
https://www.ncbi.nlm.nih.gov/pubmed/25905603
http://dx.doi.org/10.3390/molecules20047245
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