Efficient Esterification of Oxidized l-Glutathione and Other Small Peptides

Oxidized l-glutathione was esterified to the tetra methyl ester using thionyl chloride in methanol solvent. Other alcohols were tested and the reaction progress was monitored via ESI-MS. This procedure proved to be compatible with other small peptides not containing serine and cysteine residues. In...

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Detalles Bibliográficos
Autores principales: Vogel, Emily R., Jackson, William, Masterson, Douglas S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272753/
https://www.ncbi.nlm.nih.gov/pubmed/26060914
http://dx.doi.org/10.3390/molecules200610487
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author Vogel, Emily R.
Jackson, William
Masterson, Douglas S.
author_facet Vogel, Emily R.
Jackson, William
Masterson, Douglas S.
author_sort Vogel, Emily R.
collection PubMed
description Oxidized l-glutathione was esterified to the tetra methyl ester using thionyl chloride in methanol solvent. Other alcohols were tested and the reaction progress was monitored via ESI-MS. This procedure proved to be compatible with other small peptides not containing serine and cysteine residues. In contrast to previously reported methods this procedure provided convenient access to esterified peptides requiring no purification, extended reaction times, or complicated reaction setups.
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spelling pubmed-62727532018-12-31 Efficient Esterification of Oxidized l-Glutathione and Other Small Peptides Vogel, Emily R. Jackson, William Masterson, Douglas S. Molecules Communication Oxidized l-glutathione was esterified to the tetra methyl ester using thionyl chloride in methanol solvent. Other alcohols were tested and the reaction progress was monitored via ESI-MS. This procedure proved to be compatible with other small peptides not containing serine and cysteine residues. In contrast to previously reported methods this procedure provided convenient access to esterified peptides requiring no purification, extended reaction times, or complicated reaction setups. MDPI 2015-06-08 /pmc/articles/PMC6272753/ /pubmed/26060914 http://dx.doi.org/10.3390/molecules200610487 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Vogel, Emily R.
Jackson, William
Masterson, Douglas S.
Efficient Esterification of Oxidized l-Glutathione and Other Small Peptides
title Efficient Esterification of Oxidized l-Glutathione and Other Small Peptides
title_full Efficient Esterification of Oxidized l-Glutathione and Other Small Peptides
title_fullStr Efficient Esterification of Oxidized l-Glutathione and Other Small Peptides
title_full_unstemmed Efficient Esterification of Oxidized l-Glutathione and Other Small Peptides
title_short Efficient Esterification of Oxidized l-Glutathione and Other Small Peptides
title_sort efficient esterification of oxidized l-glutathione and other small peptides
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272753/
https://www.ncbi.nlm.nih.gov/pubmed/26060914
http://dx.doi.org/10.3390/molecules200610487
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