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Perinatal Asphyxia: A Review from a Metabolomics Perspective

Perinatal asphyxia is defined as an oxygen deprivation that occurs around the time of birth, and may be caused by several perinatal events. This medical condition affects some four million neonates worldwide per year, causing the death of one million subjects. In most cases, infants successfully rec...

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Autores principales: Fattuoni, Claudia, Palmas, Francesco, Noto, Antonio, Fanos, Vassilios, Barberini, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272788/
https://www.ncbi.nlm.nih.gov/pubmed/25898414
http://dx.doi.org/10.3390/molecules20047000
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author Fattuoni, Claudia
Palmas, Francesco
Noto, Antonio
Fanos, Vassilios
Barberini, Luigi
author_facet Fattuoni, Claudia
Palmas, Francesco
Noto, Antonio
Fanos, Vassilios
Barberini, Luigi
author_sort Fattuoni, Claudia
collection PubMed
description Perinatal asphyxia is defined as an oxygen deprivation that occurs around the time of birth, and may be caused by several perinatal events. This medical condition affects some four million neonates worldwide per year, causing the death of one million subjects. In most cases, infants successfully recover from hypoxia episodes; however, some patients may develop HIE, leading to permanent neurological conditions or impairment of different organs and systems. Given its multifactor dependency, the timing, severity and outcome of this disease, mainly assessed through Sarnat staging, are of difficult evaluation. Moreover, although the latest newborn resuscitation guideline suggests the use of a 21% oxygen concentration or room air, such an approach is still under debate. Therefore, the pathological mechanism is still not clear and a golden standard treatment has yet to be defined. In this context, metabolomics, a new discipline that has described important perinatal issues over the last years, proved to be a useful tool for the monitoring, the assessment, and the identification of potential biomarkers associated with asphyxia events. This review covers metabolomics research on perinatal asphyxia condition, examining in detail the studies reported both on animal and human models.
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spelling pubmed-62727882018-12-03 Perinatal Asphyxia: A Review from a Metabolomics Perspective Fattuoni, Claudia Palmas, Francesco Noto, Antonio Fanos, Vassilios Barberini, Luigi Molecules Review Perinatal asphyxia is defined as an oxygen deprivation that occurs around the time of birth, and may be caused by several perinatal events. This medical condition affects some four million neonates worldwide per year, causing the death of one million subjects. In most cases, infants successfully recover from hypoxia episodes; however, some patients may develop HIE, leading to permanent neurological conditions or impairment of different organs and systems. Given its multifactor dependency, the timing, severity and outcome of this disease, mainly assessed through Sarnat staging, are of difficult evaluation. Moreover, although the latest newborn resuscitation guideline suggests the use of a 21% oxygen concentration or room air, such an approach is still under debate. Therefore, the pathological mechanism is still not clear and a golden standard treatment has yet to be defined. In this context, metabolomics, a new discipline that has described important perinatal issues over the last years, proved to be a useful tool for the monitoring, the assessment, and the identification of potential biomarkers associated with asphyxia events. This review covers metabolomics research on perinatal asphyxia condition, examining in detail the studies reported both on animal and human models. MDPI 2015-04-17 /pmc/articles/PMC6272788/ /pubmed/25898414 http://dx.doi.org/10.3390/molecules20047000 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fattuoni, Claudia
Palmas, Francesco
Noto, Antonio
Fanos, Vassilios
Barberini, Luigi
Perinatal Asphyxia: A Review from a Metabolomics Perspective
title Perinatal Asphyxia: A Review from a Metabolomics Perspective
title_full Perinatal Asphyxia: A Review from a Metabolomics Perspective
title_fullStr Perinatal Asphyxia: A Review from a Metabolomics Perspective
title_full_unstemmed Perinatal Asphyxia: A Review from a Metabolomics Perspective
title_short Perinatal Asphyxia: A Review from a Metabolomics Perspective
title_sort perinatal asphyxia: a review from a metabolomics perspective
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272788/
https://www.ncbi.nlm.nih.gov/pubmed/25898414
http://dx.doi.org/10.3390/molecules20047000
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