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Perinatal Asphyxia: A Review from a Metabolomics Perspective
Perinatal asphyxia is defined as an oxygen deprivation that occurs around the time of birth, and may be caused by several perinatal events. This medical condition affects some four million neonates worldwide per year, causing the death of one million subjects. In most cases, infants successfully rec...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272788/ https://www.ncbi.nlm.nih.gov/pubmed/25898414 http://dx.doi.org/10.3390/molecules20047000 |
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author | Fattuoni, Claudia Palmas, Francesco Noto, Antonio Fanos, Vassilios Barberini, Luigi |
author_facet | Fattuoni, Claudia Palmas, Francesco Noto, Antonio Fanos, Vassilios Barberini, Luigi |
author_sort | Fattuoni, Claudia |
collection | PubMed |
description | Perinatal asphyxia is defined as an oxygen deprivation that occurs around the time of birth, and may be caused by several perinatal events. This medical condition affects some four million neonates worldwide per year, causing the death of one million subjects. In most cases, infants successfully recover from hypoxia episodes; however, some patients may develop HIE, leading to permanent neurological conditions or impairment of different organs and systems. Given its multifactor dependency, the timing, severity and outcome of this disease, mainly assessed through Sarnat staging, are of difficult evaluation. Moreover, although the latest newborn resuscitation guideline suggests the use of a 21% oxygen concentration or room air, such an approach is still under debate. Therefore, the pathological mechanism is still not clear and a golden standard treatment has yet to be defined. In this context, metabolomics, a new discipline that has described important perinatal issues over the last years, proved to be a useful tool for the monitoring, the assessment, and the identification of potential biomarkers associated with asphyxia events. This review covers metabolomics research on perinatal asphyxia condition, examining in detail the studies reported both on animal and human models. |
format | Online Article Text |
id | pubmed-6272788 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62727882018-12-03 Perinatal Asphyxia: A Review from a Metabolomics Perspective Fattuoni, Claudia Palmas, Francesco Noto, Antonio Fanos, Vassilios Barberini, Luigi Molecules Review Perinatal asphyxia is defined as an oxygen deprivation that occurs around the time of birth, and may be caused by several perinatal events. This medical condition affects some four million neonates worldwide per year, causing the death of one million subjects. In most cases, infants successfully recover from hypoxia episodes; however, some patients may develop HIE, leading to permanent neurological conditions or impairment of different organs and systems. Given its multifactor dependency, the timing, severity and outcome of this disease, mainly assessed through Sarnat staging, are of difficult evaluation. Moreover, although the latest newborn resuscitation guideline suggests the use of a 21% oxygen concentration or room air, such an approach is still under debate. Therefore, the pathological mechanism is still not clear and a golden standard treatment has yet to be defined. In this context, metabolomics, a new discipline that has described important perinatal issues over the last years, proved to be a useful tool for the monitoring, the assessment, and the identification of potential biomarkers associated with asphyxia events. This review covers metabolomics research on perinatal asphyxia condition, examining in detail the studies reported both on animal and human models. MDPI 2015-04-17 /pmc/articles/PMC6272788/ /pubmed/25898414 http://dx.doi.org/10.3390/molecules20047000 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Fattuoni, Claudia Palmas, Francesco Noto, Antonio Fanos, Vassilios Barberini, Luigi Perinatal Asphyxia: A Review from a Metabolomics Perspective |
title | Perinatal Asphyxia: A Review from a Metabolomics Perspective |
title_full | Perinatal Asphyxia: A Review from a Metabolomics Perspective |
title_fullStr | Perinatal Asphyxia: A Review from a Metabolomics Perspective |
title_full_unstemmed | Perinatal Asphyxia: A Review from a Metabolomics Perspective |
title_short | Perinatal Asphyxia: A Review from a Metabolomics Perspective |
title_sort | perinatal asphyxia: a review from a metabolomics perspective |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272788/ https://www.ncbi.nlm.nih.gov/pubmed/25898414 http://dx.doi.org/10.3390/molecules20047000 |
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