Cargando…

Anti-Trypanosomal Activity of Nigerian Plants and Their Constituents

African trypanosomiasis is a vector-borne parasitic disease causing serious risks to the lives of about 60 million people and 48 million cattle globally. Nigerian medicinal plants are known to contain a large variety of chemical structures and some of the plant extracts have been screened for antitr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nwodo, Ngozi Justina, Ibezim, Akachukwu, Ntie-Kang, Fidele, Adikwu, Michael Umale, Mbah, Chika John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272792/ https://www.ncbi.nlm.nih.gov/pubmed/25927903 http://dx.doi.org/10.3390/molecules20057750

Ejemplares similares

A computational multi-targeting approach for drug repositioning for psoriasis treatment
por: Ibezim, Akachukwu, et al.
Publicado: (2021)

Structure-based virtual screening and molecular dynamics simulation studies to discover new SARS-CoV-2 main protease inhibitors
por: Ibezim, A., et al.
Publicado: (2021)

Fragment-based virtual screening discovers potential new Plasmodium PI4KIIIβ ligands
por: Ibezim, Akachukwu, et al.
Publicado: (2022)

Evaluation of anti-malarial potency of new pyrazole-hydrazine coupled to Schiff base derivatives
por: Ibezim, Akachukwu, et al.
Publicado: (2022)

Experimental and In-Silico Investigation of Anti-Microbial Activity of 1-Chloro-2-Isocyanatoethane Derivatives of Thiomorpholine, Piperazine and Morpholine
por: Nwuche, Charles O., et al.
Publicado: (2017)

Anti-onchocerca Metabolites from Cyperus articulatus: Isolation, In Vitro Activity and In Silico ‘Drug-Likeness’
por: Metuge, Jonathan Alunge, et al.
Publicado: (2014)

The potential of anti-malarial compounds derived from African medicinal plants, part III: an in silico evaluation of drug metabolism and pharmacokinetics profiling
por: Onguéné, Pascal Amoa, et al.
Publicado: (2014)

Evaluation of the in vitro trypanocidal activity of methylated flavonoid constituents of Vitex simplicifolia leaves
por: Nwodo, Ngozi, et al.
Publicado: (2015)

Synthesis, molecular docking, antiplasmodial and antioxidant activities of new sulfonamido-pepetide derivatives
por: Onoabedje, Efeturi A., et al.
Publicado: (2020)

New sulphonamide pyrolidine carboxamide derivatives: Synthesis, molecular docking, antiplasmodial and antioxidant activities
por: Onoabedje, Efeturi A., et al.
Publicado: (2021)

Editorial to Special Issue—“Structure-Activity Relationships (SAR) of Natural Products”
por: Sippl, Wolfgang, et al.
Publicado: (2021)

Potent Antitrypanosomal Activities of 3-Aminosteroids against African Trypanosomes: Investigation of Cellular Effects and of Cross-Resistance with Existing Drugs
por: Nnadi, Charles O., et al.
Publicado: (2019)

Structure-Activity-Relationship and Mechanistic Insights for Anti-HIV Natural Products
por: Kaur, Ramandeep, et al.
Publicado: (2020)

Compounds from African Medicinal Plants with Activities Against Selected Parasitic Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis
por: Simoben, Conrad V., et al.
Publicado: (2018)

The use of minimal topological differences to inspire the design of novel tetrahydroisoquinoline analogues with antimalarial activity
por: Ngo Hanna, Joelleinsert, et al.
Publicado: (2021)

An in silico evaluation of the ADMET profile of the StreptomeDB database
por: Ntie-Kang, Fidele
Publicado: (2013)

Chemical constituents and anti-inflammatory activity of leaf essential oil of Nigerian grown Chenopodium album L.
por: Usman, L.A., et al.
Publicado: (2010)

A 3D-QSAR Study on the Antitrypanosomal and Cytotoxic Activities of Steroid Alkaloids by Comparative Molecular Field Analysis
por: Nnadi, Charles Okeke, et al.
Publicado: (2018)

Alkaloids with Anti-Onchocercal Activity from Voacanga africana Stapf (Apocynaceae): Identification and Molecular Modeling
por: Babiaka, Smith B., et al.
Publicado: (2020)

Oxazin-5-Ones as a Novel Class of Penicillin Binding Protein Inhibitors: Design, Synthesis and Structure Activity Relationship
por: Onoabedje, Efeturi Abraham, et al.
Publicado: (2016)

Steroid Alkaloids from Holarrhena africana with Strong Activity against Trypanosoma brucei rhodesiense
por: Nnadi, Charles Okeke, et al.
Publicado: (2017)

Protease-inhibiting, molecular modeling and antimicrobial activities of extracts and constituents from Helichrysum foetidum and Helichrysum mechowianum (compositae)
por: Malolo, Fanny-Aimée Essombe, et al.
Publicado: (2015)

The potential of anti-malarial compounds derived from African medicinal plants, part I: a pharmacological evaluation of alkaloids and terpenoids
por: Amoa Onguéné, Pascal, et al.
Publicado: (2013)

The Chemistry and Biological Activities of Natural Products from Northern African Plant Families: From Taccaceae to Zygophyllaceae
por: Ntie-Kang, Fidele, et al.
Publicado: (2016)

In silico drug metabolism and pharmacokinetic profiles of natural products from medicinal plants in the Congo basin
por: Ntie-Kang, Fidele, et al.
Publicado: (2013)

The potential of anti-malarial compounds derived from African medicinal plants, part II: a pharmacological evaluation of non-alkaloids and non-terpenoids
por: Ntie-Kang, Fidele, et al.
Publicado: (2014)

AfroDb: A Select Highly Potent and Diverse Natural Product Library from African Medicinal Plants
por: Ntie-Kang, Fidele, et al.
Publicado: (2013)

The potential of anti-malarial compounds derived from African medicinal plants: a review of pharmacological evaluations from 2013 to 2019
por: Bekono, Boris D., et al.
Publicado: (2020)

Affinity Is an Important Determinant of the Anti-Trypanosome Activity of Nanobodies
por: Caljon, Guy, et al.
Publicado: (2012)

A Bioactivity Versus Ethnobotanical Survey of Medicinal Plants from Nigeria, West Africa
por: Lifongo, Lydia L., et al.
Publicado: (2014)

Natural Products as Modulators of Sirtuins
por: Karaman Mayack, Berin, et al.
Publicado: (2020)

Anti-trypanosomal screening of Salvadoran flora
por: Castillo, Ulises G., et al.
Publicado: (2021)

Antimicrobial activity of Nigerian medicinal plants
por: Anyanwu, Madubuike Umunna, et al.
Publicado: (2017)

New Tetromycin Derivatives with Anti-Trypanosomal and Protease Inhibitory Activities
por: Pimentel-Elardo, Sheila M., et al.
Publicado: (2011)

Correction: Affinity Is an Important Determinant of the Anti-Trypanosome Activity of Nanobodies
por: Caljon, Guy, et al.
Publicado: (2012)

Orally Active and Selective Tubulin Inhibitors as Anti-Trypanosome Agents
por: Nanavaty, Vishal, et al.
Publicado: (2016)

Pharmacoinformatic Investigation of Medicinal Plants from East Africa
por: Simoben, Conrad V., et al.
Publicado: (2020)

Natural Products as Potential Lead Compounds for Drug Discovery Against SARS-CoV-2
por: Ebob, Oyere Tanyi, et al.
Publicado: (2021)

Phytochemical and Ethnopharmacological Perspectives of Ehretia laevis
por: Sharma, Pooja, et al.
Publicado: (2021)

Editorial: Natural Product Epigenetic Modulators and Inhibitors
por: Ntie-Kang, Fidele, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_i4cef4rgqhdjathuf0m1l0b2p2