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Synthesis and p38 Inhibitory Activity of Some Novel Substituted N,N′-Diarylurea Derivatives

We have identified a novel series of substituted N,N′-diarylurea p38α inhibitors. The inhibitory activity of the target compounds against the enzyme p38α, MAPKAPK2 in BHK cells, TNF-α release in LPS-stimulated THP-1 cells and p38α binding experiments were tested. Among these compounds, 25a inhibited...

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Detalles Bibliográficos
Autores principales:	Zhu, Dianxi, Xing, Qifeng, Cao, Ruiyuan, Zhao, Dongmei, Zhong, Wu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272846/ https://www.ncbi.nlm.nih.gov/pubmed/27223276 http://dx.doi.org/10.3390/molecules21050677

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