Evaluation of the Nano-TiO(2) as a Novel Deswelling Material

Nano-TiO(2) is widely applied in the automobile exhaust hose reels as a catalyst to reduce oxynitride emissions, including nitric oxide (NO). In the biomedicine field, NO plays an important role in vasodilation and edema formation in human bodies. However, the deswelling activity of nano-TiO(2) has not been reported. Here, we demonstrated that nano-TiO(2) can significantly degrade the production of NO in LPS-induced RAW264.7 mouse macrophages. Further study indicated that nano-TiO(2) exhibited an effect on vascular permeability inhibition, and prevented carrageenan-induced footpad edema. Therefore, we prepared a nano-TiO(2) ointment and observed similar deswelling effects. In conclusion, nano-TiO(2) might act as a novel deswelling agent related with its degradation of NO, which will aid in our ability to design effective interventions for edema involved diseases.