Asteltoxins with Antiviral Activities from the Marine Sponge-Derived Fungus Aspergillus sp. SCSIO XWS02F40

Two new asteltoxins named asteltoxin E (2) and F (3), and a new chromone (4), together with four known compounds were isolated from a marine sponge–derived fungus, Aspergillus sp. SCSIO XWS02F40. The structures of the compounds (1–7) were determined by the extensive 1D- and 2D-NMR spectra, and HRESI...

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Autores principales: Tian, Yong-Qi, Lin, Xiu-Ping, Wang, Zhen, Zhou, Xue-Feng, Qin, Xiao-Chu, Kaliyaperumal, Kumaravel, Zhang, Tian-Yu, Tu, Zheng-Chao, Liu, Yonghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272915/
https://www.ncbi.nlm.nih.gov/pubmed/26712735
http://dx.doi.org/10.3390/molecules21010034
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author Tian, Yong-Qi
Lin, Xiu-Ping
Wang, Zhen
Zhou, Xue-Feng
Qin, Xiao-Chu
Kaliyaperumal, Kumaravel
Zhang, Tian-Yu
Tu, Zheng-Chao
Liu, Yonghong
author_facet Tian, Yong-Qi
Lin, Xiu-Ping
Wang, Zhen
Zhou, Xue-Feng
Qin, Xiao-Chu
Kaliyaperumal, Kumaravel
Zhang, Tian-Yu
Tu, Zheng-Chao
Liu, Yonghong
author_sort Tian, Yong-Qi
collection PubMed
description Two new asteltoxins named asteltoxin E (2) and F (3), and a new chromone (4), together with four known compounds were isolated from a marine sponge–derived fungus, Aspergillus sp. SCSIO XWS02F40. The structures of the compounds (1–7) were determined by the extensive 1D- and 2D-NMR spectra, and HRESIMS spectrometry. All the compounds were tested for their antiviral (H1N1 and H3N2) activity. Compounds 2 and 3 showed significant activity against H3N2 with the prominent IC(50) values of 6.2 ± 0.08 and 8.9 ± 0.3 μM, respectively. In addition, compound 2 also exhibited inhibitory activity against H1N1 with an IC(50) value of 3.5 ± 1.3 μM.
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spelling pubmed-62729152018-12-28 Asteltoxins with Antiviral Activities from the Marine Sponge-Derived Fungus Aspergillus sp. SCSIO XWS02F40 Tian, Yong-Qi Lin, Xiu-Ping Wang, Zhen Zhou, Xue-Feng Qin, Xiao-Chu Kaliyaperumal, Kumaravel Zhang, Tian-Yu Tu, Zheng-Chao Liu, Yonghong Molecules Article Two new asteltoxins named asteltoxin E (2) and F (3), and a new chromone (4), together with four known compounds were isolated from a marine sponge–derived fungus, Aspergillus sp. SCSIO XWS02F40. The structures of the compounds (1–7) were determined by the extensive 1D- and 2D-NMR spectra, and HRESIMS spectrometry. All the compounds were tested for their antiviral (H1N1 and H3N2) activity. Compounds 2 and 3 showed significant activity against H3N2 with the prominent IC(50) values of 6.2 ± 0.08 and 8.9 ± 0.3 μM, respectively. In addition, compound 2 also exhibited inhibitory activity against H1N1 with an IC(50) value of 3.5 ± 1.3 μM. MDPI 2015-12-26 /pmc/articles/PMC6272915/ /pubmed/26712735 http://dx.doi.org/10.3390/molecules21010034 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tian, Yong-Qi
Lin, Xiu-Ping
Wang, Zhen
Zhou, Xue-Feng
Qin, Xiao-Chu
Kaliyaperumal, Kumaravel
Zhang, Tian-Yu
Tu, Zheng-Chao
Liu, Yonghong
Asteltoxins with Antiviral Activities from the Marine Sponge-Derived Fungus Aspergillus sp. SCSIO XWS02F40
title Asteltoxins with Antiviral Activities from the Marine Sponge-Derived Fungus Aspergillus sp. SCSIO XWS02F40
title_full Asteltoxins with Antiviral Activities from the Marine Sponge-Derived Fungus Aspergillus sp. SCSIO XWS02F40
title_fullStr Asteltoxins with Antiviral Activities from the Marine Sponge-Derived Fungus Aspergillus sp. SCSIO XWS02F40
title_full_unstemmed Asteltoxins with Antiviral Activities from the Marine Sponge-Derived Fungus Aspergillus sp. SCSIO XWS02F40
title_short Asteltoxins with Antiviral Activities from the Marine Sponge-Derived Fungus Aspergillus sp. SCSIO XWS02F40
title_sort asteltoxins with antiviral activities from the marine sponge-derived fungus aspergillus sp. scsio xws02f40
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272915/
https://www.ncbi.nlm.nih.gov/pubmed/26712735
http://dx.doi.org/10.3390/molecules21010034
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