Labdane Diterpenes from the Fruits of Sinopodophyllum emodi

Two new labdane diterpenes, sinoditerpene A (1) and B (2), were isolated from the fruits of Sinopodophyllum emodi, along with two known analogues 3 and 4. Their structures were established on the basis of extensive spectroscopic analysis. The isolation of compounds 1–4 represents the first report of...

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Detalles Bibliográficos
Autores principales: Sun, Yan-Jun, Gao, Mei-Ling, Zhang, Yan-Li, Wang, Jun-Min, Wu, Ya, Wang, Yu, Liu, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272936/
https://www.ncbi.nlm.nih.gov/pubmed/27043521
http://dx.doi.org/10.3390/molecules21040434
Descripción
Sumario:Two new labdane diterpenes, sinoditerpene A (1) and B (2), were isolated from the fruits of Sinopodophyllum emodi, along with two known analogues 3 and 4. Their structures were established on the basis of extensive spectroscopic analysis. The isolation of compounds 1–4 represents the first report of diterpenes from the genus Sinopodophyllum. The cytotoxic activities of all isolated compounds were evaluated in comparison with 5-fluorouracil against the MCF-7 and HepG2 cell lines, towards which 3 showed more potent cytotoxicity.

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