Labdane Diterpenes from the Fruits of Sinopodophyllum emodi

Two new labdane diterpenes, sinoditerpene A (1) and B (2), were isolated from the fruits of Sinopodophyllum emodi, along with two known analogues 3 and 4. Their structures were established on the basis of extensive spectroscopic analysis. The isolation of compounds 1–4 represents the first report of...

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Autores principales: Sun, Yan-Jun, Gao, Mei-Ling, Zhang, Yan-Li, Wang, Jun-Min, Wu, Ya, Wang, Yu, Liu, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272936/
https://www.ncbi.nlm.nih.gov/pubmed/27043521
http://dx.doi.org/10.3390/molecules21040434
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author Sun, Yan-Jun
Gao, Mei-Ling
Zhang, Yan-Li
Wang, Jun-Min
Wu, Ya
Wang, Yu
Liu, Tao
author_facet Sun, Yan-Jun
Gao, Mei-Ling
Zhang, Yan-Li
Wang, Jun-Min
Wu, Ya
Wang, Yu
Liu, Tao
author_sort Sun, Yan-Jun
collection PubMed
description Two new labdane diterpenes, sinoditerpene A (1) and B (2), were isolated from the fruits of Sinopodophyllum emodi, along with two known analogues 3 and 4. Their structures were established on the basis of extensive spectroscopic analysis. The isolation of compounds 1–4 represents the first report of diterpenes from the genus Sinopodophyllum. The cytotoxic activities of all isolated compounds were evaluated in comparison with 5-fluorouracil against the MCF-7 and HepG2 cell lines, towards which 3 showed more potent cytotoxicity.
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spelling pubmed-62729362018-12-28 Labdane Diterpenes from the Fruits of Sinopodophyllum emodi Sun, Yan-Jun Gao, Mei-Ling Zhang, Yan-Li Wang, Jun-Min Wu, Ya Wang, Yu Liu, Tao Molecules Article Two new labdane diterpenes, sinoditerpene A (1) and B (2), were isolated from the fruits of Sinopodophyllum emodi, along with two known analogues 3 and 4. Their structures were established on the basis of extensive spectroscopic analysis. The isolation of compounds 1–4 represents the first report of diterpenes from the genus Sinopodophyllum. The cytotoxic activities of all isolated compounds were evaluated in comparison with 5-fluorouracil against the MCF-7 and HepG2 cell lines, towards which 3 showed more potent cytotoxicity. MDPI 2016-03-31 /pmc/articles/PMC6272936/ /pubmed/27043521 http://dx.doi.org/10.3390/molecules21040434 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sun, Yan-Jun
Gao, Mei-Ling
Zhang, Yan-Li
Wang, Jun-Min
Wu, Ya
Wang, Yu
Liu, Tao
Labdane Diterpenes from the Fruits of Sinopodophyllum emodi
title Labdane Diterpenes from the Fruits of Sinopodophyllum emodi
title_full Labdane Diterpenes from the Fruits of Sinopodophyllum emodi
title_fullStr Labdane Diterpenes from the Fruits of Sinopodophyllum emodi
title_full_unstemmed Labdane Diterpenes from the Fruits of Sinopodophyllum emodi
title_short Labdane Diterpenes from the Fruits of Sinopodophyllum emodi
title_sort labdane diterpenes from the fruits of sinopodophyllum emodi
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272936/
https://www.ncbi.nlm.nih.gov/pubmed/27043521
http://dx.doi.org/10.3390/molecules21040434
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