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An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin
Scutellarein (2), which is an important in vivo metabolite of scutellarin (1), was synthesized from 3,4,5-trimethoxyphenol (3) in high yield in four steps. This strategy relies on acetylation, aldolization, cyclization and hydrolysis reactions, respectively.
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272953/ https://www.ncbi.nlm.nih.gov/pubmed/26927039 http://dx.doi.org/10.3390/molecules21030263 |
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author | Dong, Ze-Xi Li, Nian-Guang Zhang, Peng-Xuan Gu, Ting Wu, Wen-Yu Shi, Zhi-Hao |
author_facet | Dong, Ze-Xi Li, Nian-Guang Zhang, Peng-Xuan Gu, Ting Wu, Wen-Yu Shi, Zhi-Hao |
author_sort | Dong, Ze-Xi |
collection | PubMed |
description | Scutellarein (2), which is an important in vivo metabolite of scutellarin (1), was synthesized from 3,4,5-trimethoxyphenol (3) in high yield in four steps. This strategy relies on acetylation, aldolization, cyclization and hydrolysis reactions, respectively. |
format | Online Article Text |
id | pubmed-6272953 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62729532018-12-28 An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin Dong, Ze-Xi Li, Nian-Guang Zhang, Peng-Xuan Gu, Ting Wu, Wen-Yu Shi, Zhi-Hao Molecules Article Scutellarein (2), which is an important in vivo metabolite of scutellarin (1), was synthesized from 3,4,5-trimethoxyphenol (3) in high yield in four steps. This strategy relies on acetylation, aldolization, cyclization and hydrolysis reactions, respectively. MDPI 2016-02-25 /pmc/articles/PMC6272953/ /pubmed/26927039 http://dx.doi.org/10.3390/molecules21030263 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Dong, Ze-Xi Li, Nian-Guang Zhang, Peng-Xuan Gu, Ting Wu, Wen-Yu Shi, Zhi-Hao An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin |
title | An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin |
title_full | An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin |
title_fullStr | An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin |
title_full_unstemmed | An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin |
title_short | An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin |
title_sort | efficient chemical synthesis of scutellarein: an in vivo metabolite of scutellarin |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272953/ https://www.ncbi.nlm.nih.gov/pubmed/26927039 http://dx.doi.org/10.3390/molecules21030263 |
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