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An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin

Scutellarein (2), which is an important in vivo metabolite of scutellarin (1), was synthesized from 3,4,5-trimethoxyphenol (3) in high yield in four steps. This strategy relies on acetylation, aldolization, cyclization and hydrolysis reactions, respectively.

Detalles Bibliográficos
Autores principales: Dong, Ze-Xi, Li, Nian-Guang, Zhang, Peng-Xuan, Gu, Ting, Wu, Wen-Yu, Shi, Zhi-Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272953/
https://www.ncbi.nlm.nih.gov/pubmed/26927039
http://dx.doi.org/10.3390/molecules21030263
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author Dong, Ze-Xi
Li, Nian-Guang
Zhang, Peng-Xuan
Gu, Ting
Wu, Wen-Yu
Shi, Zhi-Hao
author_facet Dong, Ze-Xi
Li, Nian-Guang
Zhang, Peng-Xuan
Gu, Ting
Wu, Wen-Yu
Shi, Zhi-Hao
author_sort Dong, Ze-Xi
collection PubMed
description Scutellarein (2), which is an important in vivo metabolite of scutellarin (1), was synthesized from 3,4,5-trimethoxyphenol (3) in high yield in four steps. This strategy relies on acetylation, aldolization, cyclization and hydrolysis reactions, respectively.
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spelling pubmed-62729532018-12-28 An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin Dong, Ze-Xi Li, Nian-Guang Zhang, Peng-Xuan Gu, Ting Wu, Wen-Yu Shi, Zhi-Hao Molecules Article Scutellarein (2), which is an important in vivo metabolite of scutellarin (1), was synthesized from 3,4,5-trimethoxyphenol (3) in high yield in four steps. This strategy relies on acetylation, aldolization, cyclization and hydrolysis reactions, respectively. MDPI 2016-02-25 /pmc/articles/PMC6272953/ /pubmed/26927039 http://dx.doi.org/10.3390/molecules21030263 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dong, Ze-Xi
Li, Nian-Guang
Zhang, Peng-Xuan
Gu, Ting
Wu, Wen-Yu
Shi, Zhi-Hao
An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin
title An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin
title_full An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin
title_fullStr An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin
title_full_unstemmed An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin
title_short An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin
title_sort efficient chemical synthesis of scutellarein: an in vivo metabolite of scutellarin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272953/
https://www.ncbi.nlm.nih.gov/pubmed/26927039
http://dx.doi.org/10.3390/molecules21030263
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