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Steroidal Saponins from the Rhizomes of Anemarrhena asphodeloides
Four new steroid saponins 1–4 were isolated from the rhizomes of Anemarrhena asphodeloides (Asparagaceae), as well as four known saponins: anemarsaponin B (5) timosaponin D (6), timosaponin E1 (7) anemarsaponin B II (8). Their structures were established through UV and NMR as well as MS data. All th...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272963/ https://www.ncbi.nlm.nih.gov/pubmed/27548119 http://dx.doi.org/10.3390/molecules21081075 |
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| author | Yang, Bing-You Zhang, Jing Liu, Yan Kuang, Hai-Xue |
| author_facet | Yang, Bing-You Zhang, Jing Liu, Yan Kuang, Hai-Xue |
| author_sort | Yang, Bing-You |
| collection | PubMed |
| description | Four new steroid saponins 1–4 were isolated from the rhizomes of Anemarrhena asphodeloides (Asparagaceae), as well as four known saponins: anemarsaponin B (5) timosaponin D (6), timosaponin E1 (7) anemarsaponin B II (8). Their structures were established through UV and NMR as well as MS data. All the compounds were evaluated for cytotoxicity against HepG2 and SGC7901 human cancer lines. Compounds 3 and 7 displayed medium antiproliferative activities on HepG2 and SGC7901 cells, with IC(50) values of 43.90 and 57.90 μM, respectively. |
| format | Online Article Text |
| id | pubmed-6272963 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-62729632018-12-28 Steroidal Saponins from the Rhizomes of Anemarrhena asphodeloides Yang, Bing-You Zhang, Jing Liu, Yan Kuang, Hai-Xue Molecules Article Four new steroid saponins 1–4 were isolated from the rhizomes of Anemarrhena asphodeloides (Asparagaceae), as well as four known saponins: anemarsaponin B (5) timosaponin D (6), timosaponin E1 (7) anemarsaponin B II (8). Their structures were established through UV and NMR as well as MS data. All the compounds were evaluated for cytotoxicity against HepG2 and SGC7901 human cancer lines. Compounds 3 and 7 displayed medium antiproliferative activities on HepG2 and SGC7901 cells, with IC(50) values of 43.90 and 57.90 μM, respectively. MDPI 2016-08-17 /pmc/articles/PMC6272963/ /pubmed/27548119 http://dx.doi.org/10.3390/molecules21081075 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Yang, Bing-You Zhang, Jing Liu, Yan Kuang, Hai-Xue Steroidal Saponins from the Rhizomes of Anemarrhena asphodeloides |
| title | Steroidal Saponins from the Rhizomes of Anemarrhena asphodeloides |
| title_full | Steroidal Saponins from the Rhizomes of Anemarrhena asphodeloides |
| title_fullStr | Steroidal Saponins from the Rhizomes of Anemarrhena asphodeloides |
| title_full_unstemmed | Steroidal Saponins from the Rhizomes of Anemarrhena asphodeloides |
| title_short | Steroidal Saponins from the Rhizomes of Anemarrhena asphodeloides |
| title_sort | steroidal saponins from the rhizomes of anemarrhena asphodeloides |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272963/ https://www.ncbi.nlm.nih.gov/pubmed/27548119 http://dx.doi.org/10.3390/molecules21081075 |
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