Cargando…

Synthesis and Cytotoxic Effect of Some Novel 1,2-Dihydropyridin-3-carbonitrile and Nicotinonitrile Derivatives

1-(2,4-Dichlorophenyl)-3-(4-fluorophenyl)propen-1-one (1) was prepared and reacted with an active methylene compound (ethyl cyanoacetate) in the presence of ammonium acetate to give the corresponding cyanopyridone 2. Compound 2 reacted with hydrazine hydrate, malononitrile, ethyl bromoacetate and ph...

Descripción completa

Detalles Bibliográficos
Autores principales:	M. Flefel, Eman, S. Abbas, Hebat-Allah, E. Abdel Mageid, Randa, A. Zaghary, Wafaa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272992/ https://www.ncbi.nlm.nih.gov/pubmed/26729087 http://dx.doi.org/10.3390/molecules21010030

Ejemplares similares

Synthesis and Antimicrobial Evaluation of Some Novel Bis-α,β-Unsaturated Ketones, Nicotinonitrile, 1,2-Dihydropyridine-3-carbonitrile, Fused Thieno[2,3-b]pyridine and Pyrazolo[3,4-b]pyridine Derivatives
por: Altalbawy, Farag M. A.
Publicado: (2013)

Synthesis, In Vitro Antimicrobial and Cytotoxic Activities of Some New Pyrazolo[1,5-a]pyrimidine Derivatives
por: Fouda, Ahmed M., et al.
Publicado: (2019)

Investigating the continuous synthesis of a nicotinonitrile precursor to nevirapine
por: Longstreet, Ashley R, et al.
Publicado: (2013)

In vitro evaluation of dihydropyridine-3-carbonitriles as potential cytotoxic agents through PIM-1 protein kinase inhibition
por: Abnous, Khalil, et al.
Publicado: (2017)

Cytotoxic Effect of Some 1, 4-Dihydropyridine Derivatives Containing Nitroimidazole Moiety
por: Miri, Ramin, et al.
Publicado: (2011)

Design, Synthesis, Characterization, and Molluscicidal Activity Screening of New Nicotinonitrile Derivatives against Land Snails, M. cartusiana
por: Maaroof, Hend M. A., et al.
Publicado: (2022)

Synthesis, Characterization and Biological Evaluation of Some Quinoxaline Derivatives: A Promising and Potent New Class of Antitumor and Antimicrobial Agents
por: Al-Marhabi, Aisha R., et al.
Publicado: (2015)

Synthesis, Molecular Docking and Preliminary in-Vitro Cytotoxic Evaluation of Some Substituted Tetrahydro-naphthalene (2',3',4',6'-Tetra-O-Acetyl-β-D-Gluco/-Galactopyranosyl) Derivatives
por: Al-Mutairi, Maha S., et al.
Publicado: (2012)

Synthesis and Pharmacological Activities of Some New Triazolo- and Tetrazolopyrimidine Derivatives
por: Bahashwan, Saleh A., et al.
Publicado: (2013)

1-(3-Ethylphenyl)-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
por: Al-Said, Mansour S., et al.
Publicado: (2012)

Synthesis, Molecular Docking and In Vitro Screening of Some Newly Synthesized Triazolopyridine, Pyridotriazine and Pyridine–Pyrazole Hybrid Derivatives
por: Flefel, Eman M., et al.
Publicado: (2018)

Synthesis, Cytotoxic Activity and In Silico Study of Novel Dihydropyridine Carboxylic Acids Derivatives
por: Ballinas-Indilí, Ricardo, et al.
Publicado: (2023)

Cytotoxic Effects of Newly Synthesized Heterocyclic Candidates Containing Nicotinonitrile and Pyrazole Moieties on Hepatocellular and Cervical Carcinomas
por: A. El-Sayed, Amira, et al.
Publicado: (2019)

Crystal structure of 4,6-diamino-2-sulfanylidene-1,2-dihydropyridine-3-carbonitrile
por: Mohamed, Shaaban K., et al.
Publicado: (2014)

Antiproliferative Activity of Some Newly Synthesized Substituted Pyridine Candidates Using 4-(Aaryl)-6-(naphthalen-1-yl)-2-oxo-1,2-dihydropyridine-3-carbonitrile as Synthon
por: El-Sayed, Amira A., et al.
Publicado: (2021)

Synthesis of Some New Pyridazine Derivatives for Anti-HAV Evaluation
por: Flefel, Eman M., et al.
Publicado: (2017)

Crystal structure of 4-(naphthalen-2-yl)-2-oxo-6-phenyl-1,2-dihydropyridine-3-carbonitrile
por: Bui, Thai Thanh Thu, et al.
Publicado: (2023)

Cytotoxic and apoptotic potential of some coumarin and 2-amino-3-carbonitrile selenophene derivatives in prostate cancer
por: YILDIRIM, Metin, et al.
Publicado: (2021)

Synthesis of Fluorinated 3,6-Dihydropyridines and 2-(Fluoromethyl)pyridines by Electrophilic Fluorination of 1,2-Dihydropyridines with Selectfluor(®)
por: Pikun, Nadiia V., et al.
Publicado: (2020)

Application of Nanomagnetic Metal–Organic Frameworks in the Green Synthesis of Nicotinonitriles via Cooperative Vinylogous Anomeric-Based Oxidation
por: Danishyar, Bashirullah, et al.
Publicado: (2023)

Data for the cytotoxicity, self-assembling properties and synthesis of 4-pyridinium-1,4-dihydropyridines
por: Pajuste, Klavs, et al.
Publicado: (2020)

Highly Effective Thermally Activated Delayed Fluorescence Emitters Based on Symmetry and Asymmetry Nicotinonitrile Derivatives
por: Choi, Min Gyeong, et al.
Publicado: (2022)

Chiral Pyridine-3,5-bis- (L-phenylalaninyl-L-leucinyl) Schiff Base Peptides as Potential Anticancer Agents: Design, Synthesis, and Molecular Docking Studies Targeting Lactate Dehydrogenase-A
por: Amr, Abd El-Galil E., et al.
Publicado: (2020)

One-pot multicomponent green Hantzsch synthesis of 1,2-dihydropyridine derivatives with antiproliferative activity
por: Bosica, Giovanna, et al.
Publicado: (2020)

Comparison between 1,2-Dihydropyridine and 1,4-Dihydropyridine on Hydride-Donating Ability and Activity
por: Zhang, Jin-Ye, et al.
Publicado: (2022)

Cytotoxic and Infection-Controlled Investigations of Novel Dihydropyridine Hybrids: An Efficient Synthesis and Molecular-Docking Studies
por: Guda, Mallikarjuna R., et al.
Publicado: (2023)

Substituted Dihydropyridine Synthesis by Dearomatization of Pyridines
por: Heusler, Arne, et al.
Publicado: (2021)

Correction: One-pot multicomponent green Hantzsch synthesis of 1,2-dihydropyridine derivatives with antiproliferative activity
por: Bosica, Giovanna, et al.
Publicado: (2021)

Synthesis and Isomerization of Some Novel Pyrazolopyrimidine and Pyrazolotriazolopyrimidine Derivatives
por: Rashad, Aymn E., et al.
Publicado: (2014)

4-(2,4-Dichlorophenyl)-2-(1H-indol-3-yl)-6-(2-pyridyl)-1,4-dihydropyridine-4-carbonitrile
por: Ramesh, P., et al.
Publicado: (2008)

Antimicrobial, anticoagulant, and cytotoxic evaluation of multidrug resistance of new 1,4-dihydropyridine derivatives
por: Ahamed, Anis, et al.
Publicado: (2018)

6-(4-Aminophenyl)-2-ethoxy-4-(2-thienyl)nicotinonitrile
por: Fun, Hoong-Kun, et al.
Publicado: (2010)

2-Amino-4-(2,4-dichlorophenyl)-6-(naphthalen-1-yl)nicotinonitrile
por: Ye, Yuan-Feng, et al.
Publicado: (2010)

“On-Water” Catalyst-Free Ecofriendly Synthesis of the Hantzsch Dihydropyridines
por: Pramanik, Amit, et al.
Publicado: (2012)

Synthesis and Radioprotective Activity of Mitochondria Targeted Dihydropyridines In Vitro
por: Zhang, Yurui, et al.
Publicado: (2017)

Discovery of trisubstituted nicotinonitrile derivatives as novel human GCN5 inhibitors through AlphaScreen-based high throughput screening
por: Tao, Hongru, et al.
Publicado: (2019)

Synthesis and Anticonvulsant Activity of a New Series of 1,4-Dihydropyridine Derivatives
por: Kumar, R. Surendra, et al.
Publicado: (2010)

Synthesis and cloxacillin antimicrobial enhancement of 2-methylsulfonylimidazolyl-1,4-dihydropyridine derivatives
por: Akbarzadeh, T., et al.
Publicado: (2010)

Facile Three-Component Synthesis, Insecticidal and Antifungal Evaluation of Novel Dihydropyridine Derivatives
por: Yang, Guan-Zhou, et al.
Publicado: (2018)

First Organocatalytic Asymmetric Synthesis of 1-Benzamido-1,4-Dihydropyridine Derivatives
por: Auria-Luna, Fernando, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_2f9ffmgktjt85hmvndgsk1r5jd