New Iridoid Glucosides from Caryopteris incana (Thunb.) Miq. and Their α-Glucosidase Inhibitory Activities

In our continued investigations of the plant Caryopteris incana, five new iridoid glucosides 1–5, including two cis-trans-isomers, 3 and 4, along with six known compounds 6–11, were isolated from the n-butyl alcohol (n-BuOH) soluble fraction of whole dried material of Caryopteris incana. Their struc...

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Autores principales: Mao, Xu-Dong, Chou, Gui-Xin, Zhao, Sen-Miao, Zhang, Cheng-Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273012/
https://www.ncbi.nlm.nih.gov/pubmed/28009847
http://dx.doi.org/10.3390/molecules21121749
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author Mao, Xu-Dong
Chou, Gui-Xin
Zhao, Sen-Miao
Zhang, Cheng-Gang
author_facet Mao, Xu-Dong
Chou, Gui-Xin
Zhao, Sen-Miao
Zhang, Cheng-Gang
author_sort Mao, Xu-Dong
collection PubMed
description In our continued investigations of the plant Caryopteris incana, five new iridoid glucosides 1–5, including two cis-trans-isomers, 3 and 4, along with six known compounds 6–11, were isolated from the n-butyl alcohol (n-BuOH) soluble fraction of whole dried material of Caryopteris incana. Their structures were established by a combination of spectroscopic techniques, including 1D and 2D NMR and high resolution electrospray ionization mass spectroscopy (HR-ESI-MS). Furthermore, all isolates were evaluated for their yeast α-glucosidase inhibitory effects. Among these compounds, 4–8 and 10 exhibited potent inhibition of α-glucosidase.
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spelling pubmed-62730122018-12-28 New Iridoid Glucosides from Caryopteris incana (Thunb.) Miq. and Their α-Glucosidase Inhibitory Activities Mao, Xu-Dong Chou, Gui-Xin Zhao, Sen-Miao Zhang, Cheng-Gang Molecules Article In our continued investigations of the plant Caryopteris incana, five new iridoid glucosides 1–5, including two cis-trans-isomers, 3 and 4, along with six known compounds 6–11, were isolated from the n-butyl alcohol (n-BuOH) soluble fraction of whole dried material of Caryopteris incana. Their structures were established by a combination of spectroscopic techniques, including 1D and 2D NMR and high resolution electrospray ionization mass spectroscopy (HR-ESI-MS). Furthermore, all isolates were evaluated for their yeast α-glucosidase inhibitory effects. Among these compounds, 4–8 and 10 exhibited potent inhibition of α-glucosidase. MDPI 2016-12-21 /pmc/articles/PMC6273012/ /pubmed/28009847 http://dx.doi.org/10.3390/molecules21121749 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mao, Xu-Dong
Chou, Gui-Xin
Zhao, Sen-Miao
Zhang, Cheng-Gang
New Iridoid Glucosides from Caryopteris incana (Thunb.) Miq. and Their α-Glucosidase Inhibitory Activities
title New Iridoid Glucosides from Caryopteris incana (Thunb.) Miq. and Their α-Glucosidase Inhibitory Activities
title_full New Iridoid Glucosides from Caryopteris incana (Thunb.) Miq. and Their α-Glucosidase Inhibitory Activities
title_fullStr New Iridoid Glucosides from Caryopteris incana (Thunb.) Miq. and Their α-Glucosidase Inhibitory Activities
title_full_unstemmed New Iridoid Glucosides from Caryopteris incana (Thunb.) Miq. and Their α-Glucosidase Inhibitory Activities
title_short New Iridoid Glucosides from Caryopteris incana (Thunb.) Miq. and Their α-Glucosidase Inhibitory Activities
title_sort new iridoid glucosides from caryopteris incana (thunb.) miq. and their α-glucosidase inhibitory activities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273012/
https://www.ncbi.nlm.nih.gov/pubmed/28009847
http://dx.doi.org/10.3390/molecules21121749
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