Synthesis of Hydroxymethylenebisphosphonic Acid Derivatives in Different Solvents

The syntheses of hydroxymethylenebisphosphonic acid derivatives (dronic acid derivatives) starting from the corresponding substituted acetic acids and P-reagents, mainly phosphorus trichloride and phosphorous acid are surveyed according to the solvents applied. The nature of the solvent is a critica...

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Detalles Bibliográficos
Autores principales: Nagy, Dávid Illés, Grün, Alajos, Garadnay, Sándor, Greiner, István, Keglevich, György
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273038/
https://www.ncbi.nlm.nih.gov/pubmed/27529200
http://dx.doi.org/10.3390/molecules21081046
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author Nagy, Dávid Illés
Grün, Alajos
Garadnay, Sándor
Greiner, István
Keglevich, György
author_facet Nagy, Dávid Illés
Grün, Alajos
Garadnay, Sándor
Greiner, István
Keglevich, György
author_sort Nagy, Dávid Illés
collection PubMed
description The syntheses of hydroxymethylenebisphosphonic acid derivatives (dronic acid derivatives) starting from the corresponding substituted acetic acids and P-reagents, mainly phosphorus trichloride and phosphorous acid are surveyed according to the solvents applied. The nature of the solvent is a critical point due to the heterogeneity of the reaction mixtures. This review sheds light on the optimum choice and ratio of the P-reactants, and on the optimum conditions.
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spelling pubmed-62730382018-12-28 Synthesis of Hydroxymethylenebisphosphonic Acid Derivatives in Different Solvents Nagy, Dávid Illés Grün, Alajos Garadnay, Sándor Greiner, István Keglevich, György Molecules Review The syntheses of hydroxymethylenebisphosphonic acid derivatives (dronic acid derivatives) starting from the corresponding substituted acetic acids and P-reagents, mainly phosphorus trichloride and phosphorous acid are surveyed according to the solvents applied. The nature of the solvent is a critical point due to the heterogeneity of the reaction mixtures. This review sheds light on the optimum choice and ratio of the P-reactants, and on the optimum conditions. MDPI 2016-08-11 /pmc/articles/PMC6273038/ /pubmed/27529200 http://dx.doi.org/10.3390/molecules21081046 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nagy, Dávid Illés
Grün, Alajos
Garadnay, Sándor
Greiner, István
Keglevich, György
Synthesis of Hydroxymethylenebisphosphonic Acid Derivatives in Different Solvents
title Synthesis of Hydroxymethylenebisphosphonic Acid Derivatives in Different Solvents
title_full Synthesis of Hydroxymethylenebisphosphonic Acid Derivatives in Different Solvents
title_fullStr Synthesis of Hydroxymethylenebisphosphonic Acid Derivatives in Different Solvents
title_full_unstemmed Synthesis of Hydroxymethylenebisphosphonic Acid Derivatives in Different Solvents
title_short Synthesis of Hydroxymethylenebisphosphonic Acid Derivatives in Different Solvents
title_sort synthesis of hydroxymethylenebisphosphonic acid derivatives in different solvents
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273038/
https://www.ncbi.nlm.nih.gov/pubmed/27529200
http://dx.doi.org/10.3390/molecules21081046
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