Terminamines K–S, Antimetastatic Pregnane Alkaloids from the Whole Herb of Pachysandra terminalis

Nine new pregnane alkaloids (1–9), together with eight known alkaloids (10–17), were isolated from the whole herb of Pachysandra terminalis. Their structures were elucidated on the basis of spectroscopic analyses. In addition, the isolates were examined for their ability to inhibit the migration of...

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Autores principales: Li, Xiang-Yu, Yu, Yang, Jia, Miao, Jin, Mei-Na, Qin, Nan, Zhao, Chuan, Duan, Hong-Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273090/
https://www.ncbi.nlm.nih.gov/pubmed/27681716
http://dx.doi.org/10.3390/molecules21101283
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author Li, Xiang-Yu
Yu, Yang
Jia, Miao
Jin, Mei-Na
Qin, Nan
Zhao, Chuan
Duan, Hong-Quan
author_facet Li, Xiang-Yu
Yu, Yang
Jia, Miao
Jin, Mei-Na
Qin, Nan
Zhao, Chuan
Duan, Hong-Quan
author_sort Li, Xiang-Yu
collection PubMed
description Nine new pregnane alkaloids (1–9), together with eight known alkaloids (10–17), were isolated from the whole herb of Pachysandra terminalis. Their structures were elucidated on the basis of spectroscopic analyses. In addition, the isolates were examined for their ability to inhibit the migration of MDA-MB-231 cells induced by the chemokine epidermal growth factor (EGF). Alkaloids 1, 5, 7, 9, 12, and 17 presented significant anti-metastasis activities compared with the positive reagent, LY294002.
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spelling pubmed-62730902018-12-28 Terminamines K–S, Antimetastatic Pregnane Alkaloids from the Whole Herb of Pachysandra terminalis Li, Xiang-Yu Yu, Yang Jia, Miao Jin, Mei-Na Qin, Nan Zhao, Chuan Duan, Hong-Quan Molecules Article Nine new pregnane alkaloids (1–9), together with eight known alkaloids (10–17), were isolated from the whole herb of Pachysandra terminalis. Their structures were elucidated on the basis of spectroscopic analyses. In addition, the isolates were examined for their ability to inhibit the migration of MDA-MB-231 cells induced by the chemokine epidermal growth factor (EGF). Alkaloids 1, 5, 7, 9, 12, and 17 presented significant anti-metastasis activities compared with the positive reagent, LY294002. MDPI 2016-09-26 /pmc/articles/PMC6273090/ /pubmed/27681716 http://dx.doi.org/10.3390/molecules21101283 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Xiang-Yu
Yu, Yang
Jia, Miao
Jin, Mei-Na
Qin, Nan
Zhao, Chuan
Duan, Hong-Quan
Terminamines K–S, Antimetastatic Pregnane Alkaloids from the Whole Herb of Pachysandra terminalis
title Terminamines K–S, Antimetastatic Pregnane Alkaloids from the Whole Herb of Pachysandra terminalis
title_full Terminamines K–S, Antimetastatic Pregnane Alkaloids from the Whole Herb of Pachysandra terminalis
title_fullStr Terminamines K–S, Antimetastatic Pregnane Alkaloids from the Whole Herb of Pachysandra terminalis
title_full_unstemmed Terminamines K–S, Antimetastatic Pregnane Alkaloids from the Whole Herb of Pachysandra terminalis
title_short Terminamines K–S, Antimetastatic Pregnane Alkaloids from the Whole Herb of Pachysandra terminalis
title_sort terminamines k–s, antimetastatic pregnane alkaloids from the whole herb of pachysandra terminalis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273090/
https://www.ncbi.nlm.nih.gov/pubmed/27681716
http://dx.doi.org/10.3390/molecules21101283
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