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A Convenient Synthesis of 3,7′-Bisindole Derivatives
An efficient and convenient method to synthesize highly functionalized 3,7′-bisindole derivatives has been developed via a Michael addition and cyclic condensation reaction of heterocyclic ketene aminals (HKAs) with 2-(1H-indol-3-yl)cyclohexa-2,5-diene-1,4-dione derivatives in ethanol-based solvents...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273136/ https://www.ncbi.nlm.nih.gov/pubmed/27196885 http://dx.doi.org/10.3390/molecules21050638 |
| _version_ | 1783377315421487104 |
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| author | Liu, Teng Zhu, Hong-You Luo, Da-Yun Yan, Sheng-Jiao Lin, Jun |
| author_facet | Liu, Teng Zhu, Hong-You Luo, Da-Yun Yan, Sheng-Jiao Lin, Jun |
| author_sort | Liu, Teng |
| collection | PubMed |
| description | An efficient and convenient method to synthesize highly functionalized 3,7′-bisindole derivatives has been developed via a Michael addition and cyclic condensation reaction of heterocyclic ketene aminals (HKAs) with 2-(1H-indol-3-yl)cyclohexa-2,5-diene-1,4-dione derivatives in ethanol-based solvents at room temperature. This strategy provides an efficient, environmentally friendly approach for easy access to various novel 3,7′-bisindole derivatives in moderate to good yields. |
| format | Online Article Text |
| id | pubmed-6273136 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-62731362018-12-28 A Convenient Synthesis of 3,7′-Bisindole Derivatives Liu, Teng Zhu, Hong-You Luo, Da-Yun Yan, Sheng-Jiao Lin, Jun Molecules Article An efficient and convenient method to synthesize highly functionalized 3,7′-bisindole derivatives has been developed via a Michael addition and cyclic condensation reaction of heterocyclic ketene aminals (HKAs) with 2-(1H-indol-3-yl)cyclohexa-2,5-diene-1,4-dione derivatives in ethanol-based solvents at room temperature. This strategy provides an efficient, environmentally friendly approach for easy access to various novel 3,7′-bisindole derivatives in moderate to good yields. MDPI 2016-05-17 /pmc/articles/PMC6273136/ /pubmed/27196885 http://dx.doi.org/10.3390/molecules21050638 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Liu, Teng Zhu, Hong-You Luo, Da-Yun Yan, Sheng-Jiao Lin, Jun A Convenient Synthesis of 3,7′-Bisindole Derivatives |
| title | A Convenient Synthesis of 3,7′-Bisindole Derivatives |
| title_full | A Convenient Synthesis of 3,7′-Bisindole Derivatives |
| title_fullStr | A Convenient Synthesis of 3,7′-Bisindole Derivatives |
| title_full_unstemmed | A Convenient Synthesis of 3,7′-Bisindole Derivatives |
| title_short | A Convenient Synthesis of 3,7′-Bisindole Derivatives |
| title_sort | convenient synthesis of 3,7′-bisindole derivatives |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273136/ https://www.ncbi.nlm.nih.gov/pubmed/27196885 http://dx.doi.org/10.3390/molecules21050638 |
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