Synthetic Procedures Leading towards Aminobisphosphonates

Growing interest in the biological activity of aminobisphosphonates has stimulated the development of methods for their synthesis. Although several general procedures were previously elaborated to reach this goal, aminobisphosphonate chemistry is still developing quite substantially. Thus, innovativ...

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Detalles Bibliográficos
Autores principales: Chmielewska, Ewa, Kafarski, Paweł
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273145/
https://www.ncbi.nlm.nih.gov/pubmed/27827924
http://dx.doi.org/10.3390/molecules21111474
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author Chmielewska, Ewa
Kafarski, Paweł
author_facet Chmielewska, Ewa
Kafarski, Paweł
author_sort Chmielewska, Ewa
collection PubMed
description Growing interest in the biological activity of aminobisphosphonates has stimulated the development of methods for their synthesis. Although several general procedures were previously elaborated to reach this goal, aminobisphosphonate chemistry is still developing quite substantially. Thus, innovative modifications of the existing commonly used reactions, as well as development of new procedures, are presented in this review, concentrating on recent achievements. Additionally, selected examples of aminobisphosphonate derivatization illustrate their usefulness for obtaining new diagnostic and therapeutic agents.
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spelling pubmed-62731452018-12-28 Synthetic Procedures Leading towards Aminobisphosphonates Chmielewska, Ewa Kafarski, Paweł Molecules Review Growing interest in the biological activity of aminobisphosphonates has stimulated the development of methods for their synthesis. Although several general procedures were previously elaborated to reach this goal, aminobisphosphonate chemistry is still developing quite substantially. Thus, innovative modifications of the existing commonly used reactions, as well as development of new procedures, are presented in this review, concentrating on recent achievements. Additionally, selected examples of aminobisphosphonate derivatization illustrate their usefulness for obtaining new diagnostic and therapeutic agents. MDPI 2016-11-04 /pmc/articles/PMC6273145/ /pubmed/27827924 http://dx.doi.org/10.3390/molecules21111474 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chmielewska, Ewa
Kafarski, Paweł
Synthetic Procedures Leading towards Aminobisphosphonates
title Synthetic Procedures Leading towards Aminobisphosphonates
title_full Synthetic Procedures Leading towards Aminobisphosphonates
title_fullStr Synthetic Procedures Leading towards Aminobisphosphonates
title_full_unstemmed Synthetic Procedures Leading towards Aminobisphosphonates
title_short Synthetic Procedures Leading towards Aminobisphosphonates
title_sort synthetic procedures leading towards aminobisphosphonates
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273145/
https://www.ncbi.nlm.nih.gov/pubmed/27827924
http://dx.doi.org/10.3390/molecules21111474
work_keys_str_mv AT chmielewskaewa syntheticproceduresleadingtowardsaminobisphosphonates
AT kafarskipaweł syntheticproceduresleadingtowardsaminobisphosphonates

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