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Design, Synthesis, and Biological Evaluation of Novel PARP-1 Inhibitors Based on a 1H-Thieno[3,4-d] Imidazole-4-Carboxamide Scaffold

A series of poly(ADP-ribose)polymerase (PARP)-1 inhibitors containing a novel scaffold, the 1H-thieno[3,4-d]imidazole-4-carboxamide moiety, was designed and synthesized. These efforts provided some compounds with relatively good PARP-1 inhibitory activity, and among them, 16l was the most potent one...

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Detalles Bibliográficos
Autores principales:	Wang, Lingxiao, Liu, Feng, Jiang, Ning, Zhou, Wenxia, Zhou, Xinbo, Zheng, Zhibing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273152/ https://www.ncbi.nlm.nih.gov/pubmed/27304949 http://dx.doi.org/10.3390/molecules21060772

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