Synthesis and Biological Evaluation of Novel 4-Morpholino-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine Derivatives Bearing Phenylpyridine/ Phenylpyrimidine-Carboxamides

Four series of novel 4-morpholino-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine derivatives 11a–j, 12a–j, 13a–g and 14a–g bearing phenylpyridine/phenylpyrimidine- carboxamide scaffolds were designed, synthesized and their IC(50) values against three cancer cell lines (A549, PC-3 and MCF-7) were evaluat...

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Detalles Bibliográficos
Autores principales: Liu, Huimin, Wang, Wenhui, Sun, Chengyu, Wang, Caolin, Zhu, Wufu, Zheng, Pengwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273168/
https://www.ncbi.nlm.nih.gov/pubmed/27809261
http://dx.doi.org/10.3390/molecules21111447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273168/
https://www.ncbi.nlm.nih.gov/pubmed/27809261
http://dx.doi.org/10.3390/molecules21111447

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