Bioactive Diterpenoids from Clerodendrum kiangsiense

A new abeo-abietane diterpenoid, 12-methoxy-6,11,14,16-tetrahydroxy-17(15→16)-abeo-5,8,11,13-abietatetraen-3,7-dione (8), was isolated from the hydroalcoholic extract of the herb of Clerodendrum kiangsiense along with seven known diterpenoids (1–7). Their structures were identified on the basis of s...

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Autores principales: Xu, Mingfeng, Wang, Shengjia, Jia, Ouya, Zhu, Qin, Shi, Lu’e
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273191/
https://www.ncbi.nlm.nih.gov/pubmed/26784154
http://dx.doi.org/10.3390/molecules21010086
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author Xu, Mingfeng
Wang, Shengjia
Jia, Ouya
Zhu, Qin
Shi, Lu’e
author_facet Xu, Mingfeng
Wang, Shengjia
Jia, Ouya
Zhu, Qin
Shi, Lu’e
author_sort Xu, Mingfeng
collection PubMed
description A new abeo-abietane diterpenoid, 12-methoxy-6,11,14,16-tetrahydroxy-17(15→16)-abeo-5,8,11,13-abietatetraen-3,7-dione (8), was isolated from the hydroalcoholic extract of the herb of Clerodendrum kiangsiense along with seven known diterpenoids (1–7). Their structures were identified on the basis of spectroscopic analyses including two-dimensional NMR and comparison with literature data. All of these compounds were evaluated for their cytotoxic activities against the growth of human cancer cells lines HL-60, SMMC-7721, A-549 and MCF-7 by the MTT assay. The results showed that cryptojaponol (4), fortunin E (6) and 8 exhibited significant cytotoxicity against four human cancer cell lines.
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spelling pubmed-62731912018-12-28 Bioactive Diterpenoids from Clerodendrum kiangsiense Xu, Mingfeng Wang, Shengjia Jia, Ouya Zhu, Qin Shi, Lu’e Molecules Communication A new abeo-abietane diterpenoid, 12-methoxy-6,11,14,16-tetrahydroxy-17(15→16)-abeo-5,8,11,13-abietatetraen-3,7-dione (8), was isolated from the hydroalcoholic extract of the herb of Clerodendrum kiangsiense along with seven known diterpenoids (1–7). Their structures were identified on the basis of spectroscopic analyses including two-dimensional NMR and comparison with literature data. All of these compounds were evaluated for their cytotoxic activities against the growth of human cancer cells lines HL-60, SMMC-7721, A-549 and MCF-7 by the MTT assay. The results showed that cryptojaponol (4), fortunin E (6) and 8 exhibited significant cytotoxicity against four human cancer cell lines. MDPI 2016-01-15 /pmc/articles/PMC6273191/ /pubmed/26784154 http://dx.doi.org/10.3390/molecules21010086 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Xu, Mingfeng
Wang, Shengjia
Jia, Ouya
Zhu, Qin
Shi, Lu’e
Bioactive Diterpenoids from Clerodendrum kiangsiense
title Bioactive Diterpenoids from Clerodendrum kiangsiense
title_full Bioactive Diterpenoids from Clerodendrum kiangsiense
title_fullStr Bioactive Diterpenoids from Clerodendrum kiangsiense
title_full_unstemmed Bioactive Diterpenoids from Clerodendrum kiangsiense
title_short Bioactive Diterpenoids from Clerodendrum kiangsiense
title_sort bioactive diterpenoids from clerodendrum kiangsiense
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273191/
https://www.ncbi.nlm.nih.gov/pubmed/26784154
http://dx.doi.org/10.3390/molecules21010086
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AT jiaouya bioactivediterpenoidsfromclerodendrumkiangsiense
AT zhuqin bioactivediterpenoidsfromclerodendrumkiangsiense
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