Design, Synthesis and Antimycobacterial Activity of Novel Imidazo[1,2-a]pyridine Amide-Cinnamamide Hybrids

We report herein the design and synthesis of a series of novel imidazo[1,2-a]pyridine amide-cinnamamide hybrids linked via an alkyl carbon chain. All 38 new hybrids were evaluated for their antimycobacterial activity against M. tuberculosis (MTB) H37Rv ATCC 27294 using the microplate Alamar Blue ass...

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Detalles Bibliográficos
Autores principales: Li, Linhu, Li, Zhuorong, Liu, Mingliang, Shen, Weiyi, Wang, Bin, Guo, Huiyuan, Lu, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273240/
https://www.ncbi.nlm.nih.gov/pubmed/26729085
http://dx.doi.org/10.3390/molecules21010049
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author Li, Linhu
Li, Zhuorong
Liu, Mingliang
Shen, Weiyi
Wang, Bin
Guo, Huiyuan
Lu, Yu
author_facet Li, Linhu
Li, Zhuorong
Liu, Mingliang
Shen, Weiyi
Wang, Bin
Guo, Huiyuan
Lu, Yu
author_sort Li, Linhu
collection PubMed
description We report herein the design and synthesis of a series of novel imidazo[1,2-a]pyridine amide-cinnamamide hybrids linked via an alkyl carbon chain. All 38 new hybrids were evaluated for their antimycobacterial activity against M. tuberculosis (MTB) H37Rv ATCC 27294 using the microplate Alamar Blue assay (MABA). Although the hybrids are less active than the two reference compounds, the promising activity (MICs: 4 μg/mL) of 2,6-dimethylimidazo[1,2-a]pyridine amide-cinnamamide hybrids 11e and 11k could be a good starting point to further find new lead compounds against multi-drug-resistant tuberculosis.
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spelling pubmed-62732402018-12-28 Design, Synthesis and Antimycobacterial Activity of Novel Imidazo[1,2-a]pyridine Amide-Cinnamamide Hybrids Li, Linhu Li, Zhuorong Liu, Mingliang Shen, Weiyi Wang, Bin Guo, Huiyuan Lu, Yu Molecules Article We report herein the design and synthesis of a series of novel imidazo[1,2-a]pyridine amide-cinnamamide hybrids linked via an alkyl carbon chain. All 38 new hybrids were evaluated for their antimycobacterial activity against M. tuberculosis (MTB) H37Rv ATCC 27294 using the microplate Alamar Blue assay (MABA). Although the hybrids are less active than the two reference compounds, the promising activity (MICs: 4 μg/mL) of 2,6-dimethylimidazo[1,2-a]pyridine amide-cinnamamide hybrids 11e and 11k could be a good starting point to further find new lead compounds against multi-drug-resistant tuberculosis. MDPI 2015-12-30 /pmc/articles/PMC6273240/ /pubmed/26729085 http://dx.doi.org/10.3390/molecules21010049 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Linhu
Li, Zhuorong
Liu, Mingliang
Shen, Weiyi
Wang, Bin
Guo, Huiyuan
Lu, Yu
Design, Synthesis and Antimycobacterial Activity of Novel Imidazo[1,2-a]pyridine Amide-Cinnamamide Hybrids
title Design, Synthesis and Antimycobacterial Activity of Novel Imidazo[1,2-a]pyridine Amide-Cinnamamide Hybrids
title_full Design, Synthesis and Antimycobacterial Activity of Novel Imidazo[1,2-a]pyridine Amide-Cinnamamide Hybrids
title_fullStr Design, Synthesis and Antimycobacterial Activity of Novel Imidazo[1,2-a]pyridine Amide-Cinnamamide Hybrids
title_full_unstemmed Design, Synthesis and Antimycobacterial Activity of Novel Imidazo[1,2-a]pyridine Amide-Cinnamamide Hybrids
title_short Design, Synthesis and Antimycobacterial Activity of Novel Imidazo[1,2-a]pyridine Amide-Cinnamamide Hybrids
title_sort design, synthesis and antimycobacterial activity of novel imidazo[1,2-a]pyridine amide-cinnamamide hybrids
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273240/
https://www.ncbi.nlm.nih.gov/pubmed/26729085
http://dx.doi.org/10.3390/molecules21010049
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