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Microwave-Assisted Syntheses of Bioactive Seven-Membered, Macro-Sized Heterocycles and Their Fused Derivatives

This review describes the recent advances in the microwave-assisted synthesis of 7-membered and larger heterocyclic compounds. Several types of reaction for the cyclization step are discussed: Ring Closing Metathesis (RCM), Heck and Sonogashira reactions, Suzuki-Miyaura cross-coupling, dipolar cyclo...

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Autores principales: Driowya, Mohsine, Saber, Aziza, Marzag, Hamid, Demange, Luc, Bougrin, Khalid, Benhida, Rachid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273266/
https://www.ncbi.nlm.nih.gov/pubmed/27517892
http://dx.doi.org/10.3390/molecules21081032
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author Driowya, Mohsine
Saber, Aziza
Marzag, Hamid
Demange, Luc
Bougrin, Khalid
Benhida, Rachid
author_facet Driowya, Mohsine
Saber, Aziza
Marzag, Hamid
Demange, Luc
Bougrin, Khalid
Benhida, Rachid
author_sort Driowya, Mohsine
collection PubMed
description This review describes the recent advances in the microwave-assisted synthesis of 7-membered and larger heterocyclic compounds. Several types of reaction for the cyclization step are discussed: Ring Closing Metathesis (RCM), Heck and Sonogashira reactions, Suzuki-Miyaura cross-coupling, dipolar cycloadditions, multi-component reactions (Ugi, Passerini), etc. Green syntheses and solvent-free procedures have been introduced whenever possible. The syntheses discussed herein have been selected to illustrate the huge potential of microwave in the synthesis of highly functionalized molecules with potential therapeutic applications, in high yields, enhanced reaction rates and increased chemoselectivity, compared to conventional methods. More than 100 references from the recent literature are listed in this review.
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spelling pubmed-62732662018-12-28 Microwave-Assisted Syntheses of Bioactive Seven-Membered, Macro-Sized Heterocycles and Their Fused Derivatives Driowya, Mohsine Saber, Aziza Marzag, Hamid Demange, Luc Bougrin, Khalid Benhida, Rachid Molecules Review This review describes the recent advances in the microwave-assisted synthesis of 7-membered and larger heterocyclic compounds. Several types of reaction for the cyclization step are discussed: Ring Closing Metathesis (RCM), Heck and Sonogashira reactions, Suzuki-Miyaura cross-coupling, dipolar cycloadditions, multi-component reactions (Ugi, Passerini), etc. Green syntheses and solvent-free procedures have been introduced whenever possible. The syntheses discussed herein have been selected to illustrate the huge potential of microwave in the synthesis of highly functionalized molecules with potential therapeutic applications, in high yields, enhanced reaction rates and increased chemoselectivity, compared to conventional methods. More than 100 references from the recent literature are listed in this review. MDPI 2016-08-09 /pmc/articles/PMC6273266/ /pubmed/27517892 http://dx.doi.org/10.3390/molecules21081032 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Driowya, Mohsine
Saber, Aziza
Marzag, Hamid
Demange, Luc
Bougrin, Khalid
Benhida, Rachid
Microwave-Assisted Syntheses of Bioactive Seven-Membered, Macro-Sized Heterocycles and Their Fused Derivatives
title Microwave-Assisted Syntheses of Bioactive Seven-Membered, Macro-Sized Heterocycles and Their Fused Derivatives
title_full Microwave-Assisted Syntheses of Bioactive Seven-Membered, Macro-Sized Heterocycles and Their Fused Derivatives
title_fullStr Microwave-Assisted Syntheses of Bioactive Seven-Membered, Macro-Sized Heterocycles and Their Fused Derivatives
title_full_unstemmed Microwave-Assisted Syntheses of Bioactive Seven-Membered, Macro-Sized Heterocycles and Their Fused Derivatives
title_short Microwave-Assisted Syntheses of Bioactive Seven-Membered, Macro-Sized Heterocycles and Their Fused Derivatives
title_sort microwave-assisted syntheses of bioactive seven-membered, macro-sized heterocycles and their fused derivatives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273266/
https://www.ncbi.nlm.nih.gov/pubmed/27517892
http://dx.doi.org/10.3390/molecules21081032
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