Mexicanolide-Type Limonoids from the Roots of Trichilia sinensis

Four new mexicanolide-type limonoids 1–4, along with two known limonoids 5–6, were isolated from the ethanolic extracts of roots of the Traditional Chinese Medicine Trichilia sinensis. Their structures were unambiguously determined by analysis of spectroscopic data, including 1D and 2D NMR as well a...

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Autores principales: Liu, Shou-Bai, Mei, Wen-Li, Chen, Hui-Qin, Guo, Zhi-Kai, Dai, Hao-Fu, Wang, Zhu-Nian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273291/
https://www.ncbi.nlm.nih.gov/pubmed/27589710
http://dx.doi.org/10.3390/molecules21091152
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author Liu, Shou-Bai
Mei, Wen-Li
Chen, Hui-Qin
Guo, Zhi-Kai
Dai, Hao-Fu
Wang, Zhu-Nian
author_facet Liu, Shou-Bai
Mei, Wen-Li
Chen, Hui-Qin
Guo, Zhi-Kai
Dai, Hao-Fu
Wang, Zhu-Nian
author_sort Liu, Shou-Bai
collection PubMed
description Four new mexicanolide-type limonoids 1–4, along with two known limonoids 5–6, were isolated from the ethanolic extracts of roots of the Traditional Chinese Medicine Trichilia sinensis. Their structures were unambiguously determined by analysis of spectroscopic data, including 1D and 2D NMR as well as MS, and by comparison with literature data. In addition, the acetylcholinesterase (AChE) inhibitory activity of compounds 1–6 was evaluated by the Ellman method. All these compounds showed weak AChE inhibitory activity, with the inhibition percentages ranging from 18.5% to 27.8%.
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spelling pubmed-62732912018-12-28 Mexicanolide-Type Limonoids from the Roots of Trichilia sinensis Liu, Shou-Bai Mei, Wen-Li Chen, Hui-Qin Guo, Zhi-Kai Dai, Hao-Fu Wang, Zhu-Nian Molecules Article Four new mexicanolide-type limonoids 1–4, along with two known limonoids 5–6, were isolated from the ethanolic extracts of roots of the Traditional Chinese Medicine Trichilia sinensis. Their structures were unambiguously determined by analysis of spectroscopic data, including 1D and 2D NMR as well as MS, and by comparison with literature data. In addition, the acetylcholinesterase (AChE) inhibitory activity of compounds 1–6 was evaluated by the Ellman method. All these compounds showed weak AChE inhibitory activity, with the inhibition percentages ranging from 18.5% to 27.8%. MDPI 2016-08-30 /pmc/articles/PMC6273291/ /pubmed/27589710 http://dx.doi.org/10.3390/molecules21091152 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Shou-Bai
Mei, Wen-Li
Chen, Hui-Qin
Guo, Zhi-Kai
Dai, Hao-Fu
Wang, Zhu-Nian
Mexicanolide-Type Limonoids from the Roots of Trichilia sinensis
title Mexicanolide-Type Limonoids from the Roots of Trichilia sinensis
title_full Mexicanolide-Type Limonoids from the Roots of Trichilia sinensis
title_fullStr Mexicanolide-Type Limonoids from the Roots of Trichilia sinensis
title_full_unstemmed Mexicanolide-Type Limonoids from the Roots of Trichilia sinensis
title_short Mexicanolide-Type Limonoids from the Roots of Trichilia sinensis
title_sort mexicanolide-type limonoids from the roots of trichilia sinensis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273291/
https://www.ncbi.nlm.nih.gov/pubmed/27589710
http://dx.doi.org/10.3390/molecules21091152
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