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Effect of the Aged Garlic Extract on Cardiovascular Function in Metabolic Syndrome Rats
The antioxidant properties of aged garlic extract (AGE) on cardiovascular functioning (CF) in metabolic syndrome (MS) remains poorly studied. Here we study the AGE effects on CF in a rat model of MS. Control rats plus saline solution (C + SS), MS rats (30% sucrose in drinking water from weaning) plu...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273338/ https://www.ncbi.nlm.nih.gov/pubmed/27792195 http://dx.doi.org/10.3390/molecules21111425 |
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author | Pérez-Torres, Israel Torres-Narváez, Juan Carlos Pedraza-Chaverri, José Rubio-Ruiz, María Esther Díaz-Díaz, Eulises del Valle-Mondragón, Leonardo Martínez-Memije, Raúl Varela López, Elvira Guarner-Lans, Verónica |
author_facet | Pérez-Torres, Israel Torres-Narváez, Juan Carlos Pedraza-Chaverri, José Rubio-Ruiz, María Esther Díaz-Díaz, Eulises del Valle-Mondragón, Leonardo Martínez-Memije, Raúl Varela López, Elvira Guarner-Lans, Verónica |
author_sort | Pérez-Torres, Israel |
collection | PubMed |
description | The antioxidant properties of aged garlic extract (AGE) on cardiovascular functioning (CF) in metabolic syndrome (MS) remains poorly studied. Here we study the AGE effects on CF in a rat model of MS. Control rats plus saline solution (C + SS), MS rats (30% sucrose in drinking water from weaning) plus saline solution (MS + SS), control rats receiving AGE (C + AGE 125 mg/Kg/12 h) and MS rats with AGE (MS + AGE) were studied. MS + SS had increased triglycerides, systolic blood pressure, insulin, leptin, HOMA index, and advanced glycation end products. AGE returned their levels to control values (p < 0.01). Cholesterol was decreased by AGE (p = 0.05). Glutathion and GPx activity were reduced in MS + SS rats and increased with AGE (p = 0.05). Lipid peroxidation was increased in MS + SS and AGE reduced it (p = 0.001). Vascular functioning was deteriorated by MS (increased vasocontraction and reduced vasodilation) and AGE improved it (p = 0.001). Coronary vascular resistance was increased in MS rats and AGE decreased it (p = 0.001). Cardiac performance was not modified by MS but AGE increased it. NO measured in the perfusate liquid from the heart and serum citrulline, nitrites/nitrates were decreased in MS and AGE increased them (p < 0.01). In conclusion, AGE reduces MS-induced cardiovascular risk, through its anti-oxidant properties. |
format | Online Article Text |
id | pubmed-6273338 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62733382018-12-28 Effect of the Aged Garlic Extract on Cardiovascular Function in Metabolic Syndrome Rats Pérez-Torres, Israel Torres-Narváez, Juan Carlos Pedraza-Chaverri, José Rubio-Ruiz, María Esther Díaz-Díaz, Eulises del Valle-Mondragón, Leonardo Martínez-Memije, Raúl Varela López, Elvira Guarner-Lans, Verónica Molecules Article The antioxidant properties of aged garlic extract (AGE) on cardiovascular functioning (CF) in metabolic syndrome (MS) remains poorly studied. Here we study the AGE effects on CF in a rat model of MS. Control rats plus saline solution (C + SS), MS rats (30% sucrose in drinking water from weaning) plus saline solution (MS + SS), control rats receiving AGE (C + AGE 125 mg/Kg/12 h) and MS rats with AGE (MS + AGE) were studied. MS + SS had increased triglycerides, systolic blood pressure, insulin, leptin, HOMA index, and advanced glycation end products. AGE returned their levels to control values (p < 0.01). Cholesterol was decreased by AGE (p = 0.05). Glutathion and GPx activity were reduced in MS + SS rats and increased with AGE (p = 0.05). Lipid peroxidation was increased in MS + SS and AGE reduced it (p = 0.001). Vascular functioning was deteriorated by MS (increased vasocontraction and reduced vasodilation) and AGE improved it (p = 0.001). Coronary vascular resistance was increased in MS rats and AGE decreased it (p = 0.001). Cardiac performance was not modified by MS but AGE increased it. NO measured in the perfusate liquid from the heart and serum citrulline, nitrites/nitrates were decreased in MS and AGE increased them (p < 0.01). In conclusion, AGE reduces MS-induced cardiovascular risk, through its anti-oxidant properties. MDPI 2016-10-26 /pmc/articles/PMC6273338/ /pubmed/27792195 http://dx.doi.org/10.3390/molecules21111425 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pérez-Torres, Israel Torres-Narváez, Juan Carlos Pedraza-Chaverri, José Rubio-Ruiz, María Esther Díaz-Díaz, Eulises del Valle-Mondragón, Leonardo Martínez-Memije, Raúl Varela López, Elvira Guarner-Lans, Verónica Effect of the Aged Garlic Extract on Cardiovascular Function in Metabolic Syndrome Rats |
title | Effect of the Aged Garlic Extract on Cardiovascular Function in Metabolic Syndrome Rats |
title_full | Effect of the Aged Garlic Extract on Cardiovascular Function in Metabolic Syndrome Rats |
title_fullStr | Effect of the Aged Garlic Extract on Cardiovascular Function in Metabolic Syndrome Rats |
title_full_unstemmed | Effect of the Aged Garlic Extract on Cardiovascular Function in Metabolic Syndrome Rats |
title_short | Effect of the Aged Garlic Extract on Cardiovascular Function in Metabolic Syndrome Rats |
title_sort | effect of the aged garlic extract on cardiovascular function in metabolic syndrome rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273338/ https://www.ncbi.nlm.nih.gov/pubmed/27792195 http://dx.doi.org/10.3390/molecules21111425 |
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