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Piceatannol Exerts Anti-Obesity Effects in C57BL/6 Mice through Modulating Adipogenic Proteins and Gut Microbiota

Obesity is a global health concern. Piceatannol (Pic), an analog of resveratrol (Res), has many reported biological activities. In this study, we investigated the anti-obesity effect of Pic in a high-fat diet (HFD)-induced obese animal model. The results showed that Pic significantly reduced mouse b...

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Autores principales: Tung, Yen-Chen, Lin, Yu-Hsuan, Chen, Hong-Jhang, Chou, Shen-Chieh, Cheng, An-Chin, Kalyanam, Nagabhushanam, Ho, Chi-Tang, Pan, Min-Hsiung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273354/
https://www.ncbi.nlm.nih.gov/pubmed/27792146
http://dx.doi.org/10.3390/molecules21111419
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author Tung, Yen-Chen
Lin, Yu-Hsuan
Chen, Hong-Jhang
Chou, Shen-Chieh
Cheng, An-Chin
Kalyanam, Nagabhushanam
Ho, Chi-Tang
Pan, Min-Hsiung
author_facet Tung, Yen-Chen
Lin, Yu-Hsuan
Chen, Hong-Jhang
Chou, Shen-Chieh
Cheng, An-Chin
Kalyanam, Nagabhushanam
Ho, Chi-Tang
Pan, Min-Hsiung
author_sort Tung, Yen-Chen
collection PubMed
description Obesity is a global health concern. Piceatannol (Pic), an analog of resveratrol (Res), has many reported biological activities. In this study, we investigated the anti-obesity effect of Pic in a high-fat diet (HFD)-induced obese animal model. The results showed that Pic significantly reduced mouse body weight in a dose-dependent manner without affecting food intake. Serum total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL) levels, and blood glucose (GLU) were significantly lowered in Pic-treated groups. Pic significantly decreased the weight of liver, spleen, perigonadal and retroperitoneal fat compared with the HFD group. Pic significantly reduced the adipocyte cell size of perigonadal fat and decreased the weight of liver. Pic-treated mice showed higher phosphorylated adenosine 5′-monophosphate-activated protein kinase (pAMPK) and phosphorylated acetyl-CoA carboxylase (pACC) protein levels and decreased protein levels of CCAAT/enhancer-binding protein C/EBPα, peroxisome proliferator-activated receptor PPARγ and fatty acid synthase (FAS), resulting in decreased lipid accumulation in adipocytes and the liver. Pic altered the composition of the gut microbiota by increasing Firmicutes and Lactobacillus and decreasing Bacteroidetes compared with the HFD group. Collectively, these results suggest that Pic may be a candidate for obesity treatment.
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spelling pubmed-62733542018-12-28 Piceatannol Exerts Anti-Obesity Effects in C57BL/6 Mice through Modulating Adipogenic Proteins and Gut Microbiota Tung, Yen-Chen Lin, Yu-Hsuan Chen, Hong-Jhang Chou, Shen-Chieh Cheng, An-Chin Kalyanam, Nagabhushanam Ho, Chi-Tang Pan, Min-Hsiung Molecules Article Obesity is a global health concern. Piceatannol (Pic), an analog of resveratrol (Res), has many reported biological activities. In this study, we investigated the anti-obesity effect of Pic in a high-fat diet (HFD)-induced obese animal model. The results showed that Pic significantly reduced mouse body weight in a dose-dependent manner without affecting food intake. Serum total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL) levels, and blood glucose (GLU) were significantly lowered in Pic-treated groups. Pic significantly decreased the weight of liver, spleen, perigonadal and retroperitoneal fat compared with the HFD group. Pic significantly reduced the adipocyte cell size of perigonadal fat and decreased the weight of liver. Pic-treated mice showed higher phosphorylated adenosine 5′-monophosphate-activated protein kinase (pAMPK) and phosphorylated acetyl-CoA carboxylase (pACC) protein levels and decreased protein levels of CCAAT/enhancer-binding protein C/EBPα, peroxisome proliferator-activated receptor PPARγ and fatty acid synthase (FAS), resulting in decreased lipid accumulation in adipocytes and the liver. Pic altered the composition of the gut microbiota by increasing Firmicutes and Lactobacillus and decreasing Bacteroidetes compared with the HFD group. Collectively, these results suggest that Pic may be a candidate for obesity treatment. MDPI 2016-10-25 /pmc/articles/PMC6273354/ /pubmed/27792146 http://dx.doi.org/10.3390/molecules21111419 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tung, Yen-Chen
Lin, Yu-Hsuan
Chen, Hong-Jhang
Chou, Shen-Chieh
Cheng, An-Chin
Kalyanam, Nagabhushanam
Ho, Chi-Tang
Pan, Min-Hsiung
Piceatannol Exerts Anti-Obesity Effects in C57BL/6 Mice through Modulating Adipogenic Proteins and Gut Microbiota
title Piceatannol Exerts Anti-Obesity Effects in C57BL/6 Mice through Modulating Adipogenic Proteins and Gut Microbiota
title_full Piceatannol Exerts Anti-Obesity Effects in C57BL/6 Mice through Modulating Adipogenic Proteins and Gut Microbiota
title_fullStr Piceatannol Exerts Anti-Obesity Effects in C57BL/6 Mice through Modulating Adipogenic Proteins and Gut Microbiota
title_full_unstemmed Piceatannol Exerts Anti-Obesity Effects in C57BL/6 Mice through Modulating Adipogenic Proteins and Gut Microbiota
title_short Piceatannol Exerts Anti-Obesity Effects in C57BL/6 Mice through Modulating Adipogenic Proteins and Gut Microbiota
title_sort piceatannol exerts anti-obesity effects in c57bl/6 mice through modulating adipogenic proteins and gut microbiota
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273354/
https://www.ncbi.nlm.nih.gov/pubmed/27792146
http://dx.doi.org/10.3390/molecules21111419
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