Green Technique-Solvent Free Microwave Synthesis and Antimicrobial Evaluation of New Thiopyridine Arabinosides

A green protocol has been applied to synthesize a novel series of 3-cyano-2-(tri-O-acetyl-β-d-arabinopyranosylthio)pyridines in a short reaction time, in higher yields and with simpler operations, when compared with the conventional heating method. Deacetylation of the obtained acetylated arabinosid...

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Autores principales: Maghrabi, Ibrahim A., Alghamdi, Saleh, Alrobaian, Majed, Eldeab, Hany A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273357/
https://www.ncbi.nlm.nih.gov/pubmed/27104506
http://dx.doi.org/10.3390/molecules21040477
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author Maghrabi, Ibrahim A.
Alghamdi, Saleh
Alrobaian, Majed
Eldeab, Hany A.
author_facet Maghrabi, Ibrahim A.
Alghamdi, Saleh
Alrobaian, Majed
Eldeab, Hany A.
author_sort Maghrabi, Ibrahim A.
collection PubMed
description A green protocol has been applied to synthesize a novel series of 3-cyano-2-(tri-O-acetyl-β-d-arabinopyranosylthio)pyridines in a short reaction time, in higher yields and with simpler operations, when compared with the conventional heating method. Deacetylation of the obtained acetylated arabinosides produced 2-(β-d-arabinopyranosylthio)-3-cyanopyridines. The structures of the obtained products were confirmed on the basis of spectroscopic data (FT-IR, 1D, 2D-NMR). The synthesized compounds were screened for the antimicrobial activity against a selection of Gram positive and Gram negative bacteria.
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spelling pubmed-62733572018-12-28 Green Technique-Solvent Free Microwave Synthesis and Antimicrobial Evaluation of New Thiopyridine Arabinosides Maghrabi, Ibrahim A. Alghamdi, Saleh Alrobaian, Majed Eldeab, Hany A. Molecules Article A green protocol has been applied to synthesize a novel series of 3-cyano-2-(tri-O-acetyl-β-d-arabinopyranosylthio)pyridines in a short reaction time, in higher yields and with simpler operations, when compared with the conventional heating method. Deacetylation of the obtained acetylated arabinosides produced 2-(β-d-arabinopyranosylthio)-3-cyanopyridines. The structures of the obtained products were confirmed on the basis of spectroscopic data (FT-IR, 1D, 2D-NMR). The synthesized compounds were screened for the antimicrobial activity against a selection of Gram positive and Gram negative bacteria. MDPI 2016-04-19 /pmc/articles/PMC6273357/ /pubmed/27104506 http://dx.doi.org/10.3390/molecules21040477 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Maghrabi, Ibrahim A.
Alghamdi, Saleh
Alrobaian, Majed
Eldeab, Hany A.
Green Technique-Solvent Free Microwave Synthesis and Antimicrobial Evaluation of New Thiopyridine Arabinosides
title Green Technique-Solvent Free Microwave Synthesis and Antimicrobial Evaluation of New Thiopyridine Arabinosides
title_full Green Technique-Solvent Free Microwave Synthesis and Antimicrobial Evaluation of New Thiopyridine Arabinosides
title_fullStr Green Technique-Solvent Free Microwave Synthesis and Antimicrobial Evaluation of New Thiopyridine Arabinosides
title_full_unstemmed Green Technique-Solvent Free Microwave Synthesis and Antimicrobial Evaluation of New Thiopyridine Arabinosides
title_short Green Technique-Solvent Free Microwave Synthesis and Antimicrobial Evaluation of New Thiopyridine Arabinosides
title_sort green technique-solvent free microwave synthesis and antimicrobial evaluation of new thiopyridine arabinosides
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273357/
https://www.ncbi.nlm.nih.gov/pubmed/27104506
http://dx.doi.org/10.3390/molecules21040477
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