Synthesis, Biological Evaluation and Molecular Modelling of 2′-Hydroxychalcones as Acetylcholinesterase Inhibitors

A series of 2′-hydroxy- and 2′-hydroxy-4′,6′-dimethoxychalcones was synthesised and evaluated as inhibitors of human acetylcholinesterase (AChE). The majority of the compounds were found to show some activity, with the most active compounds having IC(50) values of 40–85 µM. Higher activities were ge...

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Detalles Bibliográficos
Autores principales: Sukumaran, Sri Devi, Chee, Chin Fei, Viswanathan, Geetha, Buckle, Michael J. C., Othman, Rozana, Abd. Rahman, Noorsaadah, Chung, Lip Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273369/
https://www.ncbi.nlm.nih.gov/pubmed/27455222
http://dx.doi.org/10.3390/molecules21070955

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273369/
https://www.ncbi.nlm.nih.gov/pubmed/27455222
http://dx.doi.org/10.3390/molecules21070955

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