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Synthesis, Biological Profiling and Determination of the Tubulin-Bound Conformation of 12-Aza-Epothilones (Azathilones)

12-Aza-epothilones (azathilones) incorporating quinoline side chains and bearing different N12-substituents have been synthesized via highly efficient RCM-based macrocyclizations. Quinoline-based azathilones with the side chain N-atom in the meta-position to the C15 atom in the macrocycle are highly...

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Detalles Bibliográficos
Autores principales:	Jantsch, Andrea, Nieto, Lidia, Gertsch, Jürg, Rodríguez-Salarichs, Javier, Matesanz, Ruth, Jiménez-Barbero, Jesús, Díaz, J. Fernando, Canales, Ángeles, Altmann, Karl-Heinz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273374/ https://www.ncbi.nlm.nih.gov/pubmed/27527129 http://dx.doi.org/10.3390/molecules21081010

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