New Casbane and Cembrane Diterpenoids from an Okinawan Soft Coral, Lobophytum sp.

A new rare casbane-type diterpenoid 1 and two new cembrane diterpenoids 2, 3 were isolated from an Okinawan soft coral, Lobophytum sp., together with four known cembrane diterpenoids 4–7. Their structures were elucidated by extensive analysis of spectroscopic data (1D and 2D NMR, IR, and MS) and a m...

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Autores principales: Roy, Prodip K., Ashimine, Runa, Miyazato, Haruna, Taira, Junsei, Ueda, Katsuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273427/
https://www.ncbi.nlm.nih.gov/pubmed/27223275
http://dx.doi.org/10.3390/molecules21050679
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author Roy, Prodip K.
Ashimine, Runa
Miyazato, Haruna
Taira, Junsei
Ueda, Katsuhiro
author_facet Roy, Prodip K.
Ashimine, Runa
Miyazato, Haruna
Taira, Junsei
Ueda, Katsuhiro
author_sort Roy, Prodip K.
collection PubMed
description A new rare casbane-type diterpenoid 1 and two new cembrane diterpenoids 2, 3 were isolated from an Okinawan soft coral, Lobophytum sp., together with four known cembrane diterpenoids 4–7. Their structures were elucidated by extensive analysis of spectroscopic data (1D and 2D NMR, IR, and MS) and a molecular modeling study. The new isolates showed weak anti-bacterial activity, mild cytotoxicity against HCT116 cells, and anti-inflammatory effect in LPS/IFN-γ-stimulated RAW 264.7 macrophage cells.
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spelling pubmed-62734272018-12-28 New Casbane and Cembrane Diterpenoids from an Okinawan Soft Coral, Lobophytum sp. Roy, Prodip K. Ashimine, Runa Miyazato, Haruna Taira, Junsei Ueda, Katsuhiro Molecules Article A new rare casbane-type diterpenoid 1 and two new cembrane diterpenoids 2, 3 were isolated from an Okinawan soft coral, Lobophytum sp., together with four known cembrane diterpenoids 4–7. Their structures were elucidated by extensive analysis of spectroscopic data (1D and 2D NMR, IR, and MS) and a molecular modeling study. The new isolates showed weak anti-bacterial activity, mild cytotoxicity against HCT116 cells, and anti-inflammatory effect in LPS/IFN-γ-stimulated RAW 264.7 macrophage cells. MDPI 2016-05-23 /pmc/articles/PMC6273427/ /pubmed/27223275 http://dx.doi.org/10.3390/molecules21050679 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Roy, Prodip K.
Ashimine, Runa
Miyazato, Haruna
Taira, Junsei
Ueda, Katsuhiro
New Casbane and Cembrane Diterpenoids from an Okinawan Soft Coral, Lobophytum sp.
title New Casbane and Cembrane Diterpenoids from an Okinawan Soft Coral, Lobophytum sp.
title_full New Casbane and Cembrane Diterpenoids from an Okinawan Soft Coral, Lobophytum sp.
title_fullStr New Casbane and Cembrane Diterpenoids from an Okinawan Soft Coral, Lobophytum sp.
title_full_unstemmed New Casbane and Cembrane Diterpenoids from an Okinawan Soft Coral, Lobophytum sp.
title_short New Casbane and Cembrane Diterpenoids from an Okinawan Soft Coral, Lobophytum sp.
title_sort new casbane and cembrane diterpenoids from an okinawan soft coral, lobophytum sp.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273427/
https://www.ncbi.nlm.nih.gov/pubmed/27223275
http://dx.doi.org/10.3390/molecules21050679
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