Cytotoxicity of Triterpenoid Alkaloids from Buxus microphylla against Human Tumor Cell Lines

Three new triterpenoid alkaloids, namely buxmicrophyllines P–R (1–3), were isolated from the twigs and leaves of Buxus microphylla. Their structures were elucidated on the basis of NMR and MS spectroscopic analyses. Structurally, compounds 1–3 belong to the 9,10-cycloartane type alkaloids. In additi...

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Autores principales: Bai, Shi-Tou, Zhu, Guo-Lei, Peng, Xing-Rong, Dong, Jin-Run, Yu, Mu-Yuan, Chen, Jian-Chao, Wan, Luo-Sheng, Qiu, Ming-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273435/
https://www.ncbi.nlm.nih.gov/pubmed/27571056
http://dx.doi.org/10.3390/molecules21091125
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author Bai, Shi-Tou
Zhu, Guo-Lei
Peng, Xing-Rong
Dong, Jin-Run
Yu, Mu-Yuan
Chen, Jian-Chao
Wan, Luo-Sheng
Qiu, Ming-Hua
author_facet Bai, Shi-Tou
Zhu, Guo-Lei
Peng, Xing-Rong
Dong, Jin-Run
Yu, Mu-Yuan
Chen, Jian-Chao
Wan, Luo-Sheng
Qiu, Ming-Hua
author_sort Bai, Shi-Tou
collection PubMed
description Three new triterpenoid alkaloids, namely buxmicrophyllines P–R (1–3), were isolated from the twigs and leaves of Buxus microphylla. Their structures were elucidated on the basis of NMR and MS spectroscopic analyses. Structurally, compounds 1–3 belong to the 9,10-cycloartane type alkaloids. In addition, compound 3 exhibited moderate cytotoxic activities in vitro against HL-60, SMMC-7221, A-549, MCF-7, and SW480 cell lines (with IC(50) values ranging from 4.51 to 15.58 μM).
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spelling pubmed-62734352018-12-28 Cytotoxicity of Triterpenoid Alkaloids from Buxus microphylla against Human Tumor Cell Lines Bai, Shi-Tou Zhu, Guo-Lei Peng, Xing-Rong Dong, Jin-Run Yu, Mu-Yuan Chen, Jian-Chao Wan, Luo-Sheng Qiu, Ming-Hua Molecules Article Three new triterpenoid alkaloids, namely buxmicrophyllines P–R (1–3), were isolated from the twigs and leaves of Buxus microphylla. Their structures were elucidated on the basis of NMR and MS spectroscopic analyses. Structurally, compounds 1–3 belong to the 9,10-cycloartane type alkaloids. In addition, compound 3 exhibited moderate cytotoxic activities in vitro against HL-60, SMMC-7221, A-549, MCF-7, and SW480 cell lines (with IC(50) values ranging from 4.51 to 15.58 μM). MDPI 2016-08-26 /pmc/articles/PMC6273435/ /pubmed/27571056 http://dx.doi.org/10.3390/molecules21091125 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bai, Shi-Tou
Zhu, Guo-Lei
Peng, Xing-Rong
Dong, Jin-Run
Yu, Mu-Yuan
Chen, Jian-Chao
Wan, Luo-Sheng
Qiu, Ming-Hua
Cytotoxicity of Triterpenoid Alkaloids from Buxus microphylla against Human Tumor Cell Lines
title Cytotoxicity of Triterpenoid Alkaloids from Buxus microphylla against Human Tumor Cell Lines
title_full Cytotoxicity of Triterpenoid Alkaloids from Buxus microphylla against Human Tumor Cell Lines
title_fullStr Cytotoxicity of Triterpenoid Alkaloids from Buxus microphylla against Human Tumor Cell Lines
title_full_unstemmed Cytotoxicity of Triterpenoid Alkaloids from Buxus microphylla against Human Tumor Cell Lines
title_short Cytotoxicity of Triterpenoid Alkaloids from Buxus microphylla against Human Tumor Cell Lines
title_sort cytotoxicity of triterpenoid alkaloids from buxus microphylla against human tumor cell lines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273435/
https://www.ncbi.nlm.nih.gov/pubmed/27571056
http://dx.doi.org/10.3390/molecules21091125
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