Synthesis of Chiral, Enantiopure Allylic Amines by the Julia Olefination of α-Amino Esters

The four-step conversion of a series of N-Boc-protected l-amino acid methyl esters into enantiopure N-Boc allylamines by a modified Julia olefination is described. Key steps include the reaction of a lithiated phenylalkylsulfone with amino esters, giving chiral β-ketosulfones, and the reductive elim...

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Detalles Bibliográficos
Autores principales: Benedetti, Fabio, Berti, Federico, Fanfoni, Lidia, Garbo, Michele, Regini, Giorgia, Felluga, Fulvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273449/
https://www.ncbi.nlm.nih.gov/pubmed/27338326
http://dx.doi.org/10.3390/molecules21060805

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273449/
https://www.ncbi.nlm.nih.gov/pubmed/27338326
http://dx.doi.org/10.3390/molecules21060805

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