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Synthesis of Chiral, Enantiopure Allylic Amines by the Julia Olefination of α-Amino Esters
The four-step conversion of a series of N-Boc-protected l-amino acid methyl esters into enantiopure N-Boc allylamines by a modified Julia olefination is described. Key steps include the reaction of a lithiated phenylalkylsulfone with amino esters, giving chiral β-ketosulfones, and the reductive elim...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273449/ https://www.ncbi.nlm.nih.gov/pubmed/27338326 http://dx.doi.org/10.3390/molecules21060805 |