Synthesis of 2-Alkenyl-2H-indazoles from 2-(2-Carbonylmethyl)-2H-indazoles

A procedure has been developed for synthesis of 2-alkenyl-2H-indazoles starting from 2-(2-carbonylmethyl)-2H-indazoles, which are prepared by gallium/aluminium- and aluminium-mediated, direct, regioselective alkylation of indazoles with α-bromocarbonyl compounds. The structure of 3-(2H-indazol-2-yl)...

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Autores principales: Lin, Mei-Huey, Liang, Kung-Yu, Tsai, Chang-Hsien, Chen, Yu-Chun, Hsiao, Hung-Chang, Li, Yi-Syuan, Chen, Chung-Hao, Wu, Hau-Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273450/
https://www.ncbi.nlm.nih.gov/pubmed/26907234
http://dx.doi.org/10.3390/molecules21020238
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author Lin, Mei-Huey
Liang, Kung-Yu
Tsai, Chang-Hsien
Chen, Yu-Chun
Hsiao, Hung-Chang
Li, Yi-Syuan
Chen, Chung-Hao
Wu, Hau-Chun
author_facet Lin, Mei-Huey
Liang, Kung-Yu
Tsai, Chang-Hsien
Chen, Yu-Chun
Hsiao, Hung-Chang
Li, Yi-Syuan
Chen, Chung-Hao
Wu, Hau-Chun
author_sort Lin, Mei-Huey
collection PubMed
description A procedure has been developed for synthesis of 2-alkenyl-2H-indazoles starting from 2-(2-carbonylmethyl)-2H-indazoles, which are prepared by gallium/aluminium- and aluminium-mediated, direct, regioselective alkylation of indazoles with α-bromocarbonyl compounds. The structure of 3-(2H-indazol-2-yl)-2H-chromen-2-one was proven by X-ray crystallography. The styrene- and coumarin-2H-indazoles produced by using the new method were found to have interesting fluorescence properties.
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spelling pubmed-62734502018-12-28 Synthesis of 2-Alkenyl-2H-indazoles from 2-(2-Carbonylmethyl)-2H-indazoles Lin, Mei-Huey Liang, Kung-Yu Tsai, Chang-Hsien Chen, Yu-Chun Hsiao, Hung-Chang Li, Yi-Syuan Chen, Chung-Hao Wu, Hau-Chun Molecules Article A procedure has been developed for synthesis of 2-alkenyl-2H-indazoles starting from 2-(2-carbonylmethyl)-2H-indazoles, which are prepared by gallium/aluminium- and aluminium-mediated, direct, regioselective alkylation of indazoles with α-bromocarbonyl compounds. The structure of 3-(2H-indazol-2-yl)-2H-chromen-2-one was proven by X-ray crystallography. The styrene- and coumarin-2H-indazoles produced by using the new method were found to have interesting fluorescence properties. MDPI 2016-02-19 /pmc/articles/PMC6273450/ /pubmed/26907234 http://dx.doi.org/10.3390/molecules21020238 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lin, Mei-Huey
Liang, Kung-Yu
Tsai, Chang-Hsien
Chen, Yu-Chun
Hsiao, Hung-Chang
Li, Yi-Syuan
Chen, Chung-Hao
Wu, Hau-Chun
Synthesis of 2-Alkenyl-2H-indazoles from 2-(2-Carbonylmethyl)-2H-indazoles
title Synthesis of 2-Alkenyl-2H-indazoles from 2-(2-Carbonylmethyl)-2H-indazoles
title_full Synthesis of 2-Alkenyl-2H-indazoles from 2-(2-Carbonylmethyl)-2H-indazoles
title_fullStr Synthesis of 2-Alkenyl-2H-indazoles from 2-(2-Carbonylmethyl)-2H-indazoles
title_full_unstemmed Synthesis of 2-Alkenyl-2H-indazoles from 2-(2-Carbonylmethyl)-2H-indazoles
title_short Synthesis of 2-Alkenyl-2H-indazoles from 2-(2-Carbonylmethyl)-2H-indazoles
title_sort synthesis of 2-alkenyl-2h-indazoles from 2-(2-carbonylmethyl)-2h-indazoles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273450/
https://www.ncbi.nlm.nih.gov/pubmed/26907234
http://dx.doi.org/10.3390/molecules21020238
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