Design, Synthesis and Biological Evaluation of 6-(2,6-Dichloro-3,5-dimethoxyphenyl)-4-substituted-1H-indazoles as Potent Fibroblast Growth Factor Receptor Inhibitors

Tyrosine kinase fibroblast growth factor receptor (FGFR), which is aberrant in various cancer types, is a promising target for cancer therapy. Here we reported the design, synthesis, and biological evaluation of a new series of 6-(2,6-dichloro-3,5-dimethoxyphenyl)-4-substituted-1H-indazole derivativ...

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Detalles Bibliográficos
Autores principales: Zhang, Zhen, Zhao, Dongmei, Dai, Yang, Cheng, Maosheng, Geng, Meiyu, Shen, Jingkang, Ma, Yuchi, Ai, Jing, Xiong, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273472/
https://www.ncbi.nlm.nih.gov/pubmed/27782099
http://dx.doi.org/10.3390/molecules21101407

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