Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer’s Disease

We report herein the straightforward two-step synthesis and biological assessment of novel racemic benzochromenopyrimidinones as non-hepatotoxic, acetylcholinesterase inhibitors with antioxidative properties. Among them, compound 3Bb displayed a mixed-type inhibition of human acetylcholinesterase (I...

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Detalles Bibliográficos
Autores principales: Dgachi, Youssef, Bautista-Aguilera, Oscar M., Benchekroun, Mohamed, Martin, Hélène, Bonet, Alexandre, Knez, Damijan, Godyń, Justyna, Malawska, Barbara, Gobec, Stanislav, Chioua, Mourad, Janockova, Jana, Soukup, Ondrej, Chabchoub, Fakher, Marco-Contelles, José, Ismaili, Lhassane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273488/
https://www.ncbi.nlm.nih.gov/pubmed/27187348
http://dx.doi.org/10.3390/molecules21050634

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273488/
https://www.ncbi.nlm.nih.gov/pubmed/27187348
http://dx.doi.org/10.3390/molecules21050634

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