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Two New Oleanane-Type Saponins with Anti-Proliferative Activity from Camellia oleifera Abel. Seed Cake

Two new oleanane-type saponins, named oleiferasaponins C(4) (1) and C(5) (2), were isolated from Camellia oleifera Abel. seed cake residue. Their respective structures were identified as 16α-hydroxy-22α-O-angeloyl-23α-aldehyde-28-dihydroxymethylene-olean-12-ene-3β-O-[β-d-galacto-pyranosyl-(1→2)]-[β-...

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Autores principales: Zong, Jian-Fa, Peng, Yun-Ru, Bao, Guan-Hu, Hou, Ru-Yan, Wan, Xiao-Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273491/
https://www.ncbi.nlm.nih.gov/pubmed/26861265
http://dx.doi.org/10.3390/molecules21020188
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author Zong, Jian-Fa
Peng, Yun-Ru
Bao, Guan-Hu
Hou, Ru-Yan
Wan, Xiao-Chun
author_facet Zong, Jian-Fa
Peng, Yun-Ru
Bao, Guan-Hu
Hou, Ru-Yan
Wan, Xiao-Chun
author_sort Zong, Jian-Fa
collection PubMed
description Two new oleanane-type saponins, named oleiferasaponins C(4) (1) and C(5) (2), were isolated from Camellia oleifera Abel. seed cake residue. Their respective structures were identified as 16α-hydroxy-22α-O-angeloyl-23α-aldehyde-28-dihydroxymethylene-olean-12-ene-3β-O-[β-d-galacto-pyranosyl-(1→2)]-[β-d-glucopyranosyl-(1→2)-β-d-galactopyranosy-(1→3)]-β-d-glucopyranosid-uronic acid methyl ester (1) and 16α-hydroxy-22α-O-angeloyl-23α-aldehyde-28-dihydroxy-methylene-olean-12-ene-3β-O-[β-d-galactopyranosyl-(1→2)]-[β-d-galactopyranosyl-(1→3)]-β-d-glucopyranosiduronic acid methyl ester (2) through 1D- and 2D-NMR, HR-ESI-MS, and GC-MS spectroscopic methods. The two compounds exhibited potent cytotoxic activities against five human tumor cell lines (BEL-7402, BGC-823, MCF-7, HL-60 and KB).
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spelling pubmed-62734912018-12-28 Two New Oleanane-Type Saponins with Anti-Proliferative Activity from Camellia oleifera Abel. Seed Cake Zong, Jian-Fa Peng, Yun-Ru Bao, Guan-Hu Hou, Ru-Yan Wan, Xiao-Chun Molecules Article Two new oleanane-type saponins, named oleiferasaponins C(4) (1) and C(5) (2), were isolated from Camellia oleifera Abel. seed cake residue. Their respective structures were identified as 16α-hydroxy-22α-O-angeloyl-23α-aldehyde-28-dihydroxymethylene-olean-12-ene-3β-O-[β-d-galacto-pyranosyl-(1→2)]-[β-d-glucopyranosyl-(1→2)-β-d-galactopyranosy-(1→3)]-β-d-glucopyranosid-uronic acid methyl ester (1) and 16α-hydroxy-22α-O-angeloyl-23α-aldehyde-28-dihydroxy-methylene-olean-12-ene-3β-O-[β-d-galactopyranosyl-(1→2)]-[β-d-galactopyranosyl-(1→3)]-β-d-glucopyranosiduronic acid methyl ester (2) through 1D- and 2D-NMR, HR-ESI-MS, and GC-MS spectroscopic methods. The two compounds exhibited potent cytotoxic activities against five human tumor cell lines (BEL-7402, BGC-823, MCF-7, HL-60 and KB). MDPI 2016-02-04 /pmc/articles/PMC6273491/ /pubmed/26861265 http://dx.doi.org/10.3390/molecules21020188 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zong, Jian-Fa
Peng, Yun-Ru
Bao, Guan-Hu
Hou, Ru-Yan
Wan, Xiao-Chun
Two New Oleanane-Type Saponins with Anti-Proliferative Activity from Camellia oleifera Abel. Seed Cake
title Two New Oleanane-Type Saponins with Anti-Proliferative Activity from Camellia oleifera Abel. Seed Cake
title_full Two New Oleanane-Type Saponins with Anti-Proliferative Activity from Camellia oleifera Abel. Seed Cake
title_fullStr Two New Oleanane-Type Saponins with Anti-Proliferative Activity from Camellia oleifera Abel. Seed Cake
title_full_unstemmed Two New Oleanane-Type Saponins with Anti-Proliferative Activity from Camellia oleifera Abel. Seed Cake
title_short Two New Oleanane-Type Saponins with Anti-Proliferative Activity from Camellia oleifera Abel. Seed Cake
title_sort two new oleanane-type saponins with anti-proliferative activity from camellia oleifera abel. seed cake
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273491/
https://www.ncbi.nlm.nih.gov/pubmed/26861265
http://dx.doi.org/10.3390/molecules21020188
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