Indole Alkaloids from the Leaves of Nauclea officinalis

Three new indole alkaloids, named naucleamide G (1), and nauclealomide B and C (5 and 6), were isolated from the n-BuOH-soluble fraction of an EtOH extract of the leaves of Nauclea officinalis, together with three known alkaloids, paratunamide C (2), paratunamide D (3) and paratunamide A (4). The st...

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Autores principales: Fan, Long, Liao, Cheng-Hui, Kang, Qiang-Rong, Zheng, Kai, Jiang, Ying-Chun, He, Zhen-Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273496/
https://www.ncbi.nlm.nih.gov/pubmed/27455233
http://dx.doi.org/10.3390/molecules21080968
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author Fan, Long
Liao, Cheng-Hui
Kang, Qiang-Rong
Zheng, Kai
Jiang, Ying-Chun
He, Zhen-Dan
author_facet Fan, Long
Liao, Cheng-Hui
Kang, Qiang-Rong
Zheng, Kai
Jiang, Ying-Chun
He, Zhen-Dan
author_sort Fan, Long
collection PubMed
description Three new indole alkaloids, named naucleamide G (1), and nauclealomide B and C (5 and 6), were isolated from the n-BuOH-soluble fraction of an EtOH extract of the leaves of Nauclea officinalis, together with three known alkaloids, paratunamide C (2), paratunamide D (3) and paratunamide A (4). The structures with absolute configurations of the new compounds were identified on the basis of 1D and 2D NMR, HRESIMS, acid hydrolysis and quantum chemical circular dichroism (CD) calculation. According to the structures of isolated indole alkaloids, their plausible biosynthetic pathway was deduced.
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spelling pubmed-62734962018-12-28 Indole Alkaloids from the Leaves of Nauclea officinalis Fan, Long Liao, Cheng-Hui Kang, Qiang-Rong Zheng, Kai Jiang, Ying-Chun He, Zhen-Dan Molecules Article Three new indole alkaloids, named naucleamide G (1), and nauclealomide B and C (5 and 6), were isolated from the n-BuOH-soluble fraction of an EtOH extract of the leaves of Nauclea officinalis, together with three known alkaloids, paratunamide C (2), paratunamide D (3) and paratunamide A (4). The structures with absolute configurations of the new compounds were identified on the basis of 1D and 2D NMR, HRESIMS, acid hydrolysis and quantum chemical circular dichroism (CD) calculation. According to the structures of isolated indole alkaloids, their plausible biosynthetic pathway was deduced. MDPI 2016-07-23 /pmc/articles/PMC6273496/ /pubmed/27455233 http://dx.doi.org/10.3390/molecules21080968 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fan, Long
Liao, Cheng-Hui
Kang, Qiang-Rong
Zheng, Kai
Jiang, Ying-Chun
He, Zhen-Dan
Indole Alkaloids from the Leaves of Nauclea officinalis
title Indole Alkaloids from the Leaves of Nauclea officinalis
title_full Indole Alkaloids from the Leaves of Nauclea officinalis
title_fullStr Indole Alkaloids from the Leaves of Nauclea officinalis
title_full_unstemmed Indole Alkaloids from the Leaves of Nauclea officinalis
title_short Indole Alkaloids from the Leaves of Nauclea officinalis
title_sort indole alkaloids from the leaves of nauclea officinalis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273496/
https://www.ncbi.nlm.nih.gov/pubmed/27455233
http://dx.doi.org/10.3390/molecules21080968
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