Hydrazonoyl Chlorides as Precursors for Synthesis of Novel Bis-Pyrrole Derivatives

A convenient synthesis of some novel bis-pyrrole derivatives via hydrazonoyl halides is described. Antimicrobial evaluation of some selected examples of the synthesized products was carried out. The bis-pyrrole derivative having chloro substituents showed good activity against all of the used microb...

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Autor principal: Kheder, Nabila Abdelshafy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273510/
https://www.ncbi.nlm.nih.gov/pubmed/27005604
http://dx.doi.org/10.3390/molecules21030326
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author Kheder, Nabila Abdelshafy
author_facet Kheder, Nabila Abdelshafy
author_sort Kheder, Nabila Abdelshafy
collection PubMed
description A convenient synthesis of some novel bis-pyrrole derivatives via hydrazonoyl halides is described. Antimicrobial evaluation of some selected examples of the synthesized products was carried out. The bis-pyrrole derivative having chloro substituents showed good activity against all of the used microbes. The molecular docking of the bis-pyrrole derivatives was performed by the Molecular Operating Environment (MOE) program.
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spelling pubmed-62735102018-12-28 Hydrazonoyl Chlorides as Precursors for Synthesis of Novel Bis-Pyrrole Derivatives Kheder, Nabila Abdelshafy Molecules Article A convenient synthesis of some novel bis-pyrrole derivatives via hydrazonoyl halides is described. Antimicrobial evaluation of some selected examples of the synthesized products was carried out. The bis-pyrrole derivative having chloro substituents showed good activity against all of the used microbes. The molecular docking of the bis-pyrrole derivatives was performed by the Molecular Operating Environment (MOE) program. MDPI 2016-03-09 /pmc/articles/PMC6273510/ /pubmed/27005604 http://dx.doi.org/10.3390/molecules21030326 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kheder, Nabila Abdelshafy
Hydrazonoyl Chlorides as Precursors for Synthesis of Novel Bis-Pyrrole Derivatives
title Hydrazonoyl Chlorides as Precursors for Synthesis of Novel Bis-Pyrrole Derivatives
title_full Hydrazonoyl Chlorides as Precursors for Synthesis of Novel Bis-Pyrrole Derivatives
title_fullStr Hydrazonoyl Chlorides as Precursors for Synthesis of Novel Bis-Pyrrole Derivatives
title_full_unstemmed Hydrazonoyl Chlorides as Precursors for Synthesis of Novel Bis-Pyrrole Derivatives
title_short Hydrazonoyl Chlorides as Precursors for Synthesis of Novel Bis-Pyrrole Derivatives
title_sort hydrazonoyl chlorides as precursors for synthesis of novel bis-pyrrole derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273510/
https://www.ncbi.nlm.nih.gov/pubmed/27005604
http://dx.doi.org/10.3390/molecules21030326
work_keys_str_mv AT khedernabilaabdelshafy hydrazonoylchloridesasprecursorsforsynthesisofnovelbispyrrolederivatives

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