Picrotoxane Sesquiterpene Glycosides and a Coumarin Derivative from Coriaria nepalensis and Their Neurotrophic Activity

Two picrotoxane sesquiterpene lactone glycosides, nepalactones A (1) and B (2), and one new coumarin, nepalarin (3), were isolated from the root barks of the poisonous plant Coriaria nepalensis. Their structures were elucidated via HRESIMS and 1D and 2D NMR spectroscopic analyses, and further verifi...

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Autores principales: Wang, Yuan-Yuan, Tian, Jun-Mian, Zhang, Cheng-Chen, Luo, Bo, Gao, Jin-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273530/
https://www.ncbi.nlm.nih.gov/pubmed/27754343
http://dx.doi.org/10.3390/molecules21101344
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author Wang, Yuan-Yuan
Tian, Jun-Mian
Zhang, Cheng-Chen
Luo, Bo
Gao, Jin-Ming
author_facet Wang, Yuan-Yuan
Tian, Jun-Mian
Zhang, Cheng-Chen
Luo, Bo
Gao, Jin-Ming
author_sort Wang, Yuan-Yuan
collection PubMed
description Two picrotoxane sesquiterpene lactone glycosides, nepalactones A (1) and B (2), and one new coumarin, nepalarin (3), were isolated from the root barks of the poisonous plant Coriaria nepalensis. Their structures were elucidated via HRESIMS and 1D and 2D NMR spectroscopic analyses, and further verified via transformation methods. In addition, compounds 1–3 and five semisynthetic congeners (1a–e) were assayed for the activity to induce neurite outgrowth in rat pheochromocytoma (PC12) cells. As a result, nepalactone A derivative 1c and nepalarin (3) significantly enhanced nerve growth factor (NGF)-mediated neurite outgrowth in PC12 cells.
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spelling pubmed-62735302018-12-28 Picrotoxane Sesquiterpene Glycosides and a Coumarin Derivative from Coriaria nepalensis and Their Neurotrophic Activity Wang, Yuan-Yuan Tian, Jun-Mian Zhang, Cheng-Chen Luo, Bo Gao, Jin-Ming Molecules Article Two picrotoxane sesquiterpene lactone glycosides, nepalactones A (1) and B (2), and one new coumarin, nepalarin (3), were isolated from the root barks of the poisonous plant Coriaria nepalensis. Their structures were elucidated via HRESIMS and 1D and 2D NMR spectroscopic analyses, and further verified via transformation methods. In addition, compounds 1–3 and five semisynthetic congeners (1a–e) were assayed for the activity to induce neurite outgrowth in rat pheochromocytoma (PC12) cells. As a result, nepalactone A derivative 1c and nepalarin (3) significantly enhanced nerve growth factor (NGF)-mediated neurite outgrowth in PC12 cells. MDPI 2016-10-12 /pmc/articles/PMC6273530/ /pubmed/27754343 http://dx.doi.org/10.3390/molecules21101344 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Yuan-Yuan
Tian, Jun-Mian
Zhang, Cheng-Chen
Luo, Bo
Gao, Jin-Ming
Picrotoxane Sesquiterpene Glycosides and a Coumarin Derivative from Coriaria nepalensis and Their Neurotrophic Activity
title Picrotoxane Sesquiterpene Glycosides and a Coumarin Derivative from Coriaria nepalensis and Their Neurotrophic Activity
title_full Picrotoxane Sesquiterpene Glycosides and a Coumarin Derivative from Coriaria nepalensis and Their Neurotrophic Activity
title_fullStr Picrotoxane Sesquiterpene Glycosides and a Coumarin Derivative from Coriaria nepalensis and Their Neurotrophic Activity
title_full_unstemmed Picrotoxane Sesquiterpene Glycosides and a Coumarin Derivative from Coriaria nepalensis and Their Neurotrophic Activity
title_short Picrotoxane Sesquiterpene Glycosides and a Coumarin Derivative from Coriaria nepalensis and Their Neurotrophic Activity
title_sort picrotoxane sesquiterpene glycosides and a coumarin derivative from coriaria nepalensis and their neurotrophic activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273530/
https://www.ncbi.nlm.nih.gov/pubmed/27754343
http://dx.doi.org/10.3390/molecules21101344
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