2-(2-Phenylethyl)chromone Derivatives of Agarwood Originating from Gyrinops salicifolia

Three new 2-(2-phenylethyl)chromone derivatives (1–3) and a new 2-(2-phenylethenyl)chromone derivative (4), together with two known 2-(2-phenylethyl)chromone derivatives (5–6), were isolated from agarwood originating from Gyrinops salicifolia Ridl. The structures of compounds 1–4 were elucidated by...

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Detalles Bibliográficos
Autores principales: Shao, Hang, Mei, Wen-Li, Dong, Wen-Hua, Gai, Cui-Juan, Li, Wei, Zhu, Guo-Peng, Dai, Hao-Fu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273548/
https://www.ncbi.nlm.nih.gov/pubmed/27706109
http://dx.doi.org/10.3390/molecules21101313
Descripción
Sumario:Three new 2-(2-phenylethyl)chromone derivatives (1–3) and a new 2-(2-phenylethenyl)chromone derivative (4), together with two known 2-(2-phenylethyl)chromone derivatives (5–6), were isolated from agarwood originating from Gyrinops salicifolia Ridl. The structures of compounds 1–4 were elucidated by comprehensive spectroscopic techniques (UV, IR, 1D and 2D-NMR) and MS analysis, as well as by comparison with the literature. Compounds 1, 2, and 5 showed moderate cytotoxicity against human tumor K562, BEL-7402, and SGC-7901 cell lines with IC(50) values of 5.76 to 20.1 µM.

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