Improved Schmidt Conversion of Aldehydes to Nitriles Using Azidotrimethylsilane in 1,1,1,3,3,3-Hexafluoro-2-propanol

The Schmidt reaction of aromatic aldehydes using a substoichiometric amount (40 mol %) of triflic acid is described. Low catalyst loading was enabled by a strong hydrogen-bond-donating solvent hexafluoro-2-propanol (HFIP). This improved protocol tolerates a broad scope of aldehydes with diverse func...

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Detalles Bibliográficos
Autores principales: Motiwala, Hashim F., Yin, Qin, Aubé, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273554/
https://www.ncbi.nlm.nih.gov/pubmed/26729081
http://dx.doi.org/10.3390/molecules21010045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273554/
https://www.ncbi.nlm.nih.gov/pubmed/26729081
http://dx.doi.org/10.3390/molecules21010045

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