Cargando…

Improved Schmidt Conversion of Aldehydes to Nitriles Using Azidotrimethylsilane in 1,1,1,3,3,3-Hexafluoro-2-propanol

The Schmidt reaction of aromatic aldehydes using a substoichiometric amount (40 mol %) of triflic acid is described. Low catalyst loading was enabled by a strong hydrogen-bond-donating solvent hexafluoro-2-propanol (HFIP). This improved protocol tolerates a broad scope of aldehydes with diverse func...

Descripción completa

Detalles Bibliográficos
Autores principales:	Motiwala, Hashim F., Yin, Qin, Aubé, Jeffrey
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273554/ https://www.ncbi.nlm.nih.gov/pubmed/26729081 http://dx.doi.org/10.3390/molecules21010045

Ejemplares similares

Volatile Anesthetic Sevoflurane Precursor 1,1,1,3,3,3-Hexafluoro-2-Propanol (HFIP) Exerts an Anti-Prion Activity in Prion-Infected Culture Cells
por: Shimizu, Takuto, et al.
Publicado: (2021)

Examination of Solvent Interactions with Trp-Cage in 1,1,1,3,3,3-Hexafluoro-2-propanol-water at 298 K through MD Simulations and Intermolecular Nuclear Overhauser Effects
por: Gerig, J. T.
Publicado: (2023)

4,4′-(1,1,1,3,3,3-Hexafluoropropane-2,2-diyl)dibenzoic acid
por: Tang, Long, et al.
Publicado: (2010)

Structure Water-Solubility Relationship in α-Helix-Rich Films Cast From Aqueous and 1,1,1,3,3,3-Hexafluoro-2-Propanol Solutions of S. c. ricini Silk Fibroin
por: Moseti, Kelvin O., et al.
Publicado: (2019)

1,1,1,3,3,3-Hexafluoro-2-Propanol-Promoted Friedel–Crafts Reaction: Metal-Free Synthesis of C3-Difluoromethyl Carbinol-Containing Imidazo[1,2-a]pyridines at Room Temperature
por: Gao, Juanjuan, et al.
Publicado: (2023)

1,1,1,3,3,3-Hexafluoro-2,2-bis[4-(4-nitrophenoxy)phenyl]propane
por: Nawaz, H., et al.
Publicado: (2008)

Tetrakis[μ(2)-1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)propan-2-olato]tetrakis(μ(3)-2-methylpropan-2-olato)octacopper(I)
por: Purdy, Andrew P., et al.
Publicado: (2021)

Ethylenation of aldehydes to 3-propanal, propanol and propanoic acid derivatives
por: Payne, Daniel T., et al.
Publicado: (2017)

Effects of hexafluoro-2-propanol on inflammatory and hemodynamic responses in a rat model of endotoxic shock
por: Urner, M, et al.
Publicado: (2012)

Poly[tetrakis(μ-1,1,1,3,3,3-hexafluoropropan-2-olato)iron(II)dipotassium]
por: Purdy, Andrew P., et al.
Publicado: (2014)

Crystal structures of 2-bromo-1,1,1,3,3,3-hexamethyl-2-(trimethylsilyl)trisilane and 2-bromo-1,1,1,3,3,3-hexaisopropyl-2-(triisopropylsilyl)trisilane
por: Gulotty, Eva M., et al.
Publicado: (2018)

3,3′-Dimethyl-1,1′-(propane-1,3-diyl)diimidazol-1-ium bis(hexafluorophosphate)
por: Liang, Jin-hua, et al.
Publicado: (2008)

Bis(1,2-dimethoxyethane)-1κ(2) O,O′;3κ(2) O,O′-tetrakis(μ-1,1,1,3,3,3-hexafluoro-2-methylpropan-2-olato)-1:2κ(4) O:O;2:3κ(4) O:O-1,3-dilithium-2-magnesium
por: Wurst, Klaus, et al.
Publicado: (2012)

Copper(I)-catalyzed tandem reaction: synthesis of 1,4-disubstituted 1,2,3-triazoles from alkyl diacyl peroxides, azidotrimethylsilane, and alkynes
por: Israr, Muhammad, et al.
Publicado: (2018)

2,2-Bis[3,5-bis(dimethylamino)phenyl]-1,1,1,3,3,3-hexamethyltrisilane
por: Mizuhata, Yoshiyuki, et al.
Publicado: (2020)

(S)-2-(1H-Imidazol-1-yl)-3-phenylpropanol
por: Yang, Zuxing, et al.
Publicado: (2008)

Molten Globule-Like Partially Folded State of Bacillus licheniformis α-Amylase at Low pH Induced by 1,1,1,3,3,3-Hexafluoroisopropanol
por: Abd Halim, Adyani Azizah, et al.
Publicado: (2014)

New 1-Aryl-3-Substituted Propanol Derivatives as Antimalarial Agents
por: Pérez-Silanes, Silvia, et al.
Publicado: (2009)

3,3,4,4,5,5-Hexafluoro-1,2-bis(5-formyl-2-methylsulfanyl-3-thienyl)cyclopent-1-ene
por: Tu, Qidong, et al.
Publicado: (2008)

(3-Aminophenyl)diphenylphosphine oxide–2-propanol (1/1)
por: Mahdavi, Hossein, et al.
Publicado: (2008)

The crystal structure of the decaaluminum alkoxide cluster Al(10)O(4)(OH)(8) L (14) (L = 1,1,1,3,3,3-hexafluoropropan-2-olate)
por: Butcher, Ray J., et al.
Publicado: (2021)

3-(1,3-Dioxoisoindolin-2-yl)propanenitrile
por: Li, Xiao-Jun, et al.
Publicado: (2007)

3-Oxo-3-(piperidin-1-yl)propanenitrile
por: Fun, Hoong-Kun, et al.
Publicado: (2012)

3-(2,3-Dioxoindolin-1-yl)propanenitrile
por: Qachchachi, Fatima-Zahrae, et al.
Publicado: (2014)

(±)-syn-Isopropyl 4-(1,1,1,3,3,3-hexafluoropropan-2-yloxy)-1-hydroxy-3-methyl-2-(prop-1-ynyl)cyclopent-2-enecarboxylate
por: Gille, Annika, et al.
Publicado: (2009)

Ultrasound Irradiation Promoted Enzymatic Transesterification of (R/S)-1-Chloro-3-(1-naphthyloxy)-2-propanol
por: Wang, Feng, et al.
Publicado: (2012)

3-(1H-Imidazol-1-yl)propanenitrile
por: Peppel, Tim, et al.
Publicado: (2009)

3,3,4,4,5,5-Hexafluoro-1,2-bis[4-(phenylethynyl)phenyl]cyclopentene
por: Liu, Shaoqian, et al.
Publicado: (2009)

Tetramethyl N,N′-(2,2,3,3,4,4-hexafluoro-1,5-dioxopentane-1,5-diyl)bis(phosphoramidate)
por: Trush, Victor A., et al.
Publicado: (2012)

5-Bromobenzene-1,3-dicarbonitrile
por: Seidel, Nadine, et al.
Publicado: (2013)

1,3-Thiazole-4-carbonitrile
por: Fait, Martin J. G., et al.
Publicado: (2021)

Evaluation of Maternal Toxicity in Rats Exposed to 1,3-Dichloro-2-propanol during Pregnancy
por: Lee, Jong-Chan, et al.
Publicado: (2008)

Propanol and 1, 3-propanediol enhance fatty acid accumulation synergistically in Schizochytrium ATCC 20888
por: Wang, Tiantian, et al.
Publicado: (2023)

Chemical Stability and Characterization of Degradation Products of Blends of 1-(2-Hydroxyethyl)pyrrolidine and 3-Amino-1-propanol
por: Vevelstad, Solrun Johanne, et al.
Publicado: (2022)

Reproductive toxicology. 1-Chloro-2-propanol.
Publicado: (1997)

Reaction of 1-propanol with Ozone in Aqueous Media
por: Reisz, Erika, et al.
Publicado: (2019)

3,3′-(2-Oxocyclopentane-1,3-diyl)dipropanenitrile
por: Deng, Yi, et al.
Publicado: (2008)

A straightforward conversion of 1,4-quinones into polycyclic pyrazoles via [3 + 2]-cycloaddition with fluorinated nitrile imines
por: Utecht-Jarzyńska, Greta, et al.
Publicado: (2021)

1,1,1,5,5,5-Hexafluoro-2,4-dimethoxypentane-2,4-diol
por: Koen, Renier, et al.
Publicado: (2011)

Experimental and Density Functional Theory Studies on 1,1,1,4,4,4-Hexafluoro-2-Butene Pyrolysis
por: Tao, Neng, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_na2p304233608ruu4rohnho7d3