Cargando…

Inhibition of CYP2B6 by Medicinal Plant Extracts: Implication for Use of Efavirenz and Nevirapine-Based Highly Active Anti-Retroviral Therapy (HAART) in Resource-Limited Settings

Highly active antiretroviral therapy (HAART) has greatly improved health parameters of HIV infected individuals. However, there are several challenges associated with the chronic nature of HAART administration. For populations in health transition, dual use of medicinal plant extracts and convention...

Descripción completa

Detalles Bibliográficos
Autores principales:	Thomford, Nicholas E., Awortwe, Charles, Dzobo, Kevin, Adu, Faustina, Chopera, Denis, Wonkam, Ambroise, Skelton, Michelle, Blackhurst, Dee, Dandara, Collet
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273559/ https://www.ncbi.nlm.nih.gov/pubmed/26891286 http://dx.doi.org/10.3390/molecules21020211

Ejemplares similares

In Vitro Reversible and Time-Dependent CYP450 Inhibition Profiles of Medicinal Herbal Plant Extracts Newbouldia laevis and Cassia abbreviata: Implications for Herb-Drug Interactions
por: Thomford, Nicholas Ekow, et al.
Publicado: (2016)

Pharmacogenomics Implications of Using Herbal Medicinal Plants on African Populations in Health Transition
por: Thomford, Nicholas E., et al.
Publicado: (2015)

Advances in Therapeutic Targeting of Cancer Stem Cells within the Tumor Microenvironment: An Updated Review
por: Dzobo, Kevin, et al.
Publicado: (2020)

Chemoresistance to Cancer Treatment: Benzo-α-Pyrene as Friend or Foe?
por: Dzobo, Kevin, et al.
Publicado: (2018)

Incidence and Determinants of Nevirapine and Efavirenz-Related Skin Rashes in West Africans: Nevirapine's Epitaph?
por: Sarfo, Fred Stephen, et al.
Publicado: (2014)

Fibroblast-Derived Extracellular Matrix Induces Chondrogenic Differentiation in Human Adipose-Derived Mesenchymal Stromal/Stem Cells in Vitro
por: Dzobo, Kevin, et al.
Publicado: (2016)

The influence of nevirapine and efavirenz-based anti-retroviral therapy on the pharmacokinetics of lumefantrine and anti-malarial dose recommendation in HIV-malaria co-treatment
por: Maganda, Betty A, et al.
Publicado: (2015)

The Role of Tumor Microenvironment in Chemoresistance: 3D Extracellular Matrices as Accomplices
por: Senthebane, Dimakatso Alice, et al.
Publicado: (2018)

Association of CYP2B6 Genetic Variation with Efavirenz and Nevirapine Drug Resistance in HIV-1 Patients from Botswana
por: Maseng, Monkgomotsi J, et al.
Publicado: (2021)

Wharton's Jelly-Derived Mesenchymal Stromal Cells and Fibroblast-Derived Extracellular Matrix Synergistically Activate Apoptosis in a p21-Dependent Mechanism in WHCO1 and MDA MB 231 Cancer Cells In Vitro
por: Dzobo, Kevin, et al.
Publicado: (2016)

Association of CYP2B6 Genetic Variation with Efavirenz and Nevirapine Drug Resistance in HIV-1 Patients from Botswana [Corrigendum]
Publicado: (2021)

The role of CYP2B6 516G>T polymorphism on efavirenz/nevirapine toxicity. Implications on treatment outcomes: Lessons from Botswana
por: Maseng, Monkgomotsi J., et al.
Publicado: (2022)

The relation between efavirenz versus nevirapine and virologic failure in Johannesburg, South Africa
por: Shearer, Kate, et al.
Publicado: (2014)

Nevirapine or efavirenz for tuberculosis and HIV coinfected patients: exposure and virological failure relationship
por: Bhatt, Nilesh B., et al.
Publicado: (2015)

MicroRNA Mediated Changes in Drug Metabolism and Target Gene Expression by Efavirenz and Rifampicin In Vitro: Clinical Implications
por: Swart, Marelize, et al.
Publicado: (2019)

The Extracellular Matrix: Its Composition, Function, Remodeling, and Role in Tumorigenesis
por: Dzobo, Kevin, et al.
Publicado: (2023)

Case report: Severe central nervous system manifestations associated with aberrant efavirenz metabolism in children: the role of CYP2B6 genetic variation
por: Pinillos, Francoise, et al.
Publicado: (2016)

CYP2B6 c.983T>C polymorphism is associated with nevirapine hypersensitivity in Malawian and Ugandan HIV populations
por: Carr, Daniel F., et al.
Publicado: (2014)

An Expanded Analysis of Pharmacogenetics Determinants of Efavirenz Response that Includes 3′-UTR Single Nucleotide Polymorphisms among Black South African HIV/AIDS Patients
por: Swart, Marelize, et al.
Publicado: (2016)

Genetics of hearing loss in Africans: use of next generation sequencing is the best way forward
por: Lebeko, Kamogelo, et al.
Publicado: (2015)

Whole exome sequencing reveals pathogenic variants in MYO3A, MYO15A and COL9A3 and differential frequencies in ancestral alleles in hearing impairment genes among individuals from Cameroon
por: Wonkam, Ambroise, et al.
Publicado: (2020)

Heterozygous p.Asp50Asn mutation in the GJB2 gene in two Cameroonian patients with keratitis-ichthyosis-deafness (KID) syndrome
por: Wonkam, Ambroise, et al.
Publicado: (2013)

Significant pharmacokinetic interactions between artemether/lumefantrine and efavirenz or nevirapine in HIV-infected Ugandan adults
por: Byakika-Kibwika, Pauline, et al.
Publicado: (2012)

Genetic variation in the 3′-UTR of CYP1A2, CYP2B6, CYP2D6, CYP3A4, NR1I2, and UGT2B7: potential effects on regulation by microRNA and pharmacogenomics relevance
por: Swart, Marelize, et al.
Publicado: (2014)

Genetic variation in toll like receptors 2, 7, 9 and interleukin-6 is associated with cytomegalovirus infection in late pregnancy
por: Mhandire, Doreen Z., et al.
Publicado: (2020)

The Tumor Microenvironment in Tumorigenesis and Therapy Resistance Revisited
por: Dzobo, Kevin, et al.
Publicado: (2023)

Advances in Regenerative Medicine and Tissue Engineering: Innovation and Transformation of Medicine
por: Dzobo, Kevin, et al.
Publicado: (2018)

Role of Rilpivirine and Etravirine in Efavirenz and Nevirapine-Based Regimens Failure in a Resource-Limited Country: A Cross- Sectional Study
por: Teeranaipong, Phairote, et al.
Publicado: (2016)

Influence of non-nucleoside reverse transcriptase inhibitors (efavirenz and nevirapine) on the pharmacodynamic activity of gliclazide in animal models
por: Mastan, SK, et al.
Publicado: (2009)

More virological failure with lamivudine than emtricitabine in efavirenz and nevirapine regimens in the Dutch nationwide HIV Cohort
por: Rokx, Casper, et al.
Publicado: (2014)

Association between social psychological status and efavirenz and nevirapine plasma concentration among HIV patients in Kenya
por: Ngayo, Musa Otieno, et al.
Publicado: (2021)

ABCB1 4036A>G and 1236C>T Polymorphisms Affect Plasma Efavirenz Levels in South African HIV/AIDS Patients
por: Swart, Marelize, et al.
Publicado: (2012)

Effects of CYP2B6 G516T polymorphisms on plasma efavirenz and nevirapine levels when co-administered with rifampicin in HIV/TB co-infected Thai adults
por: Uttayamakul, Sumonmal, et al.
Publicado: (2010)

PXR and CAR single nucleotide polymorphisms influence plasma efavirenz levels in South African HIV/AIDS patients
por: Swart, Marelize, et al.
Publicado: (2012)

Nevirapine and Efavirenz Elicit Different Changes in Lipid Profiles in Antiretroviral- Therapy-Naive Patients Infected with HIV-1
por: van Leth, Frank, et al.
Publicado: (2004)

Disease burden and the role of pharmacogenomics in African populations
por: Mpye, K. L., et al.
Publicado: (2017)

Promoting Undetectable Equals Untransmittable in Sub-Saharan Africa: Implication for Clinical Practice and ART Adherence
por: Thomford, Nicholas Ekow, et al.
Publicado: (2020)

Competency-based Training Needs Assessment for Research Managers and Administrators in Africa and the United Kingdom to Strengthen Equitable Partnerships
por: Nembaware, Victoria, et al.
Publicado: (2022)

Profiling of warfarin pharmacokinetics‐associated genetic variants: Black Africans portray unique genetic markers important for an African specific warfarin pharmacogenetics‐dosing algorithm
por: Ndadza, Arinao, et al.
Publicado: (2021)

Correction: Nevirapine and Efavirenz Elicit Different Changes in Lipid Profiles in Antiretroviral-Therapy-Naive Patients Infected with HIV-1
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_ujcjqo5vavoov9v60c8gook317