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Effects of Resveratrol Supplementation and Exercise Training on Exercise Performance in Middle-Aged Mice

Resveratrol (RES) has antioxidative, anti-inflammatory, anticancer, antidiabetic, antiasthmatic, antalgic, and anti-fatigue activities. Exercise training (ET) improves frailty resulting from aging. This study evaluated the effects of a combination of RES supplementation and ET on the exercise perfor...

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Autores principales: Kan, Nai-Wen, Ho, Chin-Shan, Chiu, Yen-Shuo, Huang, Wen-Ching, Chen, Pei-Yu, Tung, Yu-Tang, Huang, Chi-Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273571/
https://www.ncbi.nlm.nih.gov/pubmed/27213310
http://dx.doi.org/10.3390/molecules21050661
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author Kan, Nai-Wen
Ho, Chin-Shan
Chiu, Yen-Shuo
Huang, Wen-Ching
Chen, Pei-Yu
Tung, Yu-Tang
Huang, Chi-Chang
author_facet Kan, Nai-Wen
Ho, Chin-Shan
Chiu, Yen-Shuo
Huang, Wen-Ching
Chen, Pei-Yu
Tung, Yu-Tang
Huang, Chi-Chang
author_sort Kan, Nai-Wen
collection PubMed
description Resveratrol (RES) has antioxidative, anti-inflammatory, anticancer, antidiabetic, antiasthmatic, antalgic, and anti-fatigue activities. Exercise training (ET) improves frailty resulting from aging. This study evaluated the effects of a combination of RES supplementation and ET on the exercise performance of aged mice. C57BL/6J mice (16 months old) were randomly divided into four groups: an older control group (OC group), supplementation with RES group (RES group), ET group (ET group), and a combination of ET and RES supplementation group (ET+RES group). Other 10-week-old mice were used as a young control group (Y-Ctrl group). In this study, exercise performance was evaluated using forelimb grip strength and exhaustive swimming time, as well as levels of plasma lactate, ammonia, glucose, and creatine kinase after an acute swimming exercise. Our results showed that the forelimb grip strength of mice in the ET+RES group was significantly higher than those in the OC, RES, and ET groups (by 1.3-, 1.2-, and 1.1-fold, respectively, p < 0.05), and exhibited no difference with the Y-Ctrl group. The endurance swimming test showed that swimming times of the ET and ET+RES groups were significantly longer than those of the OC and RES groups. Moreover, plasma lactate and ammonia levels of the ET + RES group after acute swimming exercise were significantly lower compared to the OC group (p < 0.05). Thus, it was suggested that by combining RES supplementation with ET for 4 weeks, the muscle strength and endurance performance of aged mice were significantly improved compared to the single intervention with either RES or ET alone. This combination might help shorten the extent of deterioration accompanying the aging process.
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spelling pubmed-62735712018-12-28 Effects of Resveratrol Supplementation and Exercise Training on Exercise Performance in Middle-Aged Mice Kan, Nai-Wen Ho, Chin-Shan Chiu, Yen-Shuo Huang, Wen-Ching Chen, Pei-Yu Tung, Yu-Tang Huang, Chi-Chang Molecules Article Resveratrol (RES) has antioxidative, anti-inflammatory, anticancer, antidiabetic, antiasthmatic, antalgic, and anti-fatigue activities. Exercise training (ET) improves frailty resulting from aging. This study evaluated the effects of a combination of RES supplementation and ET on the exercise performance of aged mice. C57BL/6J mice (16 months old) were randomly divided into four groups: an older control group (OC group), supplementation with RES group (RES group), ET group (ET group), and a combination of ET and RES supplementation group (ET+RES group). Other 10-week-old mice were used as a young control group (Y-Ctrl group). In this study, exercise performance was evaluated using forelimb grip strength and exhaustive swimming time, as well as levels of plasma lactate, ammonia, glucose, and creatine kinase after an acute swimming exercise. Our results showed that the forelimb grip strength of mice in the ET+RES group was significantly higher than those in the OC, RES, and ET groups (by 1.3-, 1.2-, and 1.1-fold, respectively, p < 0.05), and exhibited no difference with the Y-Ctrl group. The endurance swimming test showed that swimming times of the ET and ET+RES groups were significantly longer than those of the OC and RES groups. Moreover, plasma lactate and ammonia levels of the ET + RES group after acute swimming exercise were significantly lower compared to the OC group (p < 0.05). Thus, it was suggested that by combining RES supplementation with ET for 4 weeks, the muscle strength and endurance performance of aged mice were significantly improved compared to the single intervention with either RES or ET alone. This combination might help shorten the extent of deterioration accompanying the aging process. MDPI 2016-05-18 /pmc/articles/PMC6273571/ /pubmed/27213310 http://dx.doi.org/10.3390/molecules21050661 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kan, Nai-Wen
Ho, Chin-Shan
Chiu, Yen-Shuo
Huang, Wen-Ching
Chen, Pei-Yu
Tung, Yu-Tang
Huang, Chi-Chang
Effects of Resveratrol Supplementation and Exercise Training on Exercise Performance in Middle-Aged Mice
title Effects of Resveratrol Supplementation and Exercise Training on Exercise Performance in Middle-Aged Mice
title_full Effects of Resveratrol Supplementation and Exercise Training on Exercise Performance in Middle-Aged Mice
title_fullStr Effects of Resveratrol Supplementation and Exercise Training on Exercise Performance in Middle-Aged Mice
title_full_unstemmed Effects of Resveratrol Supplementation and Exercise Training on Exercise Performance in Middle-Aged Mice
title_short Effects of Resveratrol Supplementation and Exercise Training on Exercise Performance in Middle-Aged Mice
title_sort effects of resveratrol supplementation and exercise training on exercise performance in middle-aged mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273571/
https://www.ncbi.nlm.nih.gov/pubmed/27213310
http://dx.doi.org/10.3390/molecules21050661
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