Halichoblelide D, a New Elaiophylin Derivative with Potent Cytotoxic Activity from Mangrove-Derived Streptomyces sp. 219807

During our search for interesting bioactive secondary metabolites from mangrove actinomycetes, the strain Streptomyces sp. 219807 which produced a high elaiophylin yield of 4486 mg/L was obtained. A new elaiophylin derivative, halichoblelide D (1), along with seven known analogues 2–8 was isolated a...

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Autores principales: Han, Ying, Tian, Erli, Xu, Dongbo, Ma, Min, Deng, Zixin, Hong, Kui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273579/
https://www.ncbi.nlm.nih.gov/pubmed/27463707
http://dx.doi.org/10.3390/molecules21080970
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author Han, Ying
Tian, Erli
Xu, Dongbo
Ma, Min
Deng, Zixin
Hong, Kui
author_facet Han, Ying
Tian, Erli
Xu, Dongbo
Ma, Min
Deng, Zixin
Hong, Kui
author_sort Han, Ying
collection PubMed
description During our search for interesting bioactive secondary metabolites from mangrove actinomycetes, the strain Streptomyces sp. 219807 which produced a high elaiophylin yield of 4486 mg/L was obtained. A new elaiophylin derivative, halichoblelide D (1), along with seven known analogues 2–8 was isolated and identified from the culture broth. Their chemical structures were determined by detailed analysis of 1D and 2D NMR and HRMS data. The absolute configuration of halichoblelide D (1) was confirmed by comparing the CD spectrum with those of the reported analogues. Compounds 1–7 exhibited potent cytotoxic activities against HeLa and MCF-7 cells with IC(50) values ranging from 0.19 to 2.12 μM.
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spelling pubmed-62735792018-12-28 Halichoblelide D, a New Elaiophylin Derivative with Potent Cytotoxic Activity from Mangrove-Derived Streptomyces sp. 219807 Han, Ying Tian, Erli Xu, Dongbo Ma, Min Deng, Zixin Hong, Kui Molecules Article During our search for interesting bioactive secondary metabolites from mangrove actinomycetes, the strain Streptomyces sp. 219807 which produced a high elaiophylin yield of 4486 mg/L was obtained. A new elaiophylin derivative, halichoblelide D (1), along with seven known analogues 2–8 was isolated and identified from the culture broth. Their chemical structures were determined by detailed analysis of 1D and 2D NMR and HRMS data. The absolute configuration of halichoblelide D (1) was confirmed by comparing the CD spectrum with those of the reported analogues. Compounds 1–7 exhibited potent cytotoxic activities against HeLa and MCF-7 cells with IC(50) values ranging from 0.19 to 2.12 μM. MDPI 2016-07-25 /pmc/articles/PMC6273579/ /pubmed/27463707 http://dx.doi.org/10.3390/molecules21080970 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Han, Ying
Tian, Erli
Xu, Dongbo
Ma, Min
Deng, Zixin
Hong, Kui
Halichoblelide D, a New Elaiophylin Derivative with Potent Cytotoxic Activity from Mangrove-Derived Streptomyces sp. 219807
title Halichoblelide D, a New Elaiophylin Derivative with Potent Cytotoxic Activity from Mangrove-Derived Streptomyces sp. 219807
title_full Halichoblelide D, a New Elaiophylin Derivative with Potent Cytotoxic Activity from Mangrove-Derived Streptomyces sp. 219807
title_fullStr Halichoblelide D, a New Elaiophylin Derivative with Potent Cytotoxic Activity from Mangrove-Derived Streptomyces sp. 219807
title_full_unstemmed Halichoblelide D, a New Elaiophylin Derivative with Potent Cytotoxic Activity from Mangrove-Derived Streptomyces sp. 219807
title_short Halichoblelide D, a New Elaiophylin Derivative with Potent Cytotoxic Activity from Mangrove-Derived Streptomyces sp. 219807
title_sort halichoblelide d, a new elaiophylin derivative with potent cytotoxic activity from mangrove-derived streptomyces sp. 219807
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273579/
https://www.ncbi.nlm.nih.gov/pubmed/27463707
http://dx.doi.org/10.3390/molecules21080970
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