Sesquiterpenoids and Diterpenoids from the Wood of Cunninghamia konishii and Their Inhibitory Activities against NO Production

Three new sesquiterpenoids, 2α-hydroxy-3,3,6α,9β-tetramethyltricyclo[4,3,2(1,4)]undecane (1), 11-acetoxyeudesman-4β-ol (4), and 2α,3β-dihydroxy-4β-methyl-6,8,10-cadinatriene (6), four known sesquiterpenoids (2, 3, 5, and 7), together with eight known diterpenoids (8–15), were isolated from the wood...

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Autores principales: Chang, Chi-I, Chen, Chien-Chih, Chao, Che-Yi, Wang, Sheng-Yang, Chang, Hsun-Shuo, Sung, Ping-Jyun, Huang, Guan-Jhong, Li, Yen-Cheng, Kuo, Yueh-Hsiung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273599/
https://www.ncbi.nlm.nih.gov/pubmed/27089309
http://dx.doi.org/10.3390/molecules21040490
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author Chang, Chi-I
Chen, Chien-Chih
Chao, Che-Yi
Wang, Sheng-Yang
Chang, Hsun-Shuo
Sung, Ping-Jyun
Huang, Guan-Jhong
Li, Yen-Cheng
Kuo, Yueh-Hsiung
author_facet Chang, Chi-I
Chen, Chien-Chih
Chao, Che-Yi
Wang, Sheng-Yang
Chang, Hsun-Shuo
Sung, Ping-Jyun
Huang, Guan-Jhong
Li, Yen-Cheng
Kuo, Yueh-Hsiung
author_sort Chang, Chi-I
collection PubMed
description Three new sesquiterpenoids, 2α-hydroxy-3,3,6α,9β-tetramethyltricyclo[4,3,2(1,4)]undecane (1), 11-acetoxyeudesman-4β-ol (4), and 2α,3β-dihydroxy-4β-methyl-6,8,10-cadinatriene (6), four known sesquiterpenoids (2, 3, 5, and 7), together with eight known diterpenoids (8–15), were isolated from the wood of Cunninghamia konishii. Their structures were determined by detailed analysis of spectroscopic data and comparison with the data of known analogues. Four sesquiterpenoids (1, 4, 5, and 6) and all the diterpenoids (8–15) were evaluated for inhibition of nitric oxide production in lipopolysaccharides (LPS)-activated RAW 264.7 macrophages and the results showed that compounds 10 and 15 exhibited moderate inhibitory activities against nitric oxide production.
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spelling pubmed-62735992018-12-28 Sesquiterpenoids and Diterpenoids from the Wood of Cunninghamia konishii and Their Inhibitory Activities against NO Production Chang, Chi-I Chen, Chien-Chih Chao, Che-Yi Wang, Sheng-Yang Chang, Hsun-Shuo Sung, Ping-Jyun Huang, Guan-Jhong Li, Yen-Cheng Kuo, Yueh-Hsiung Molecules Article Three new sesquiterpenoids, 2α-hydroxy-3,3,6α,9β-tetramethyltricyclo[4,3,2(1,4)]undecane (1), 11-acetoxyeudesman-4β-ol (4), and 2α,3β-dihydroxy-4β-methyl-6,8,10-cadinatriene (6), four known sesquiterpenoids (2, 3, 5, and 7), together with eight known diterpenoids (8–15), were isolated from the wood of Cunninghamia konishii. Their structures were determined by detailed analysis of spectroscopic data and comparison with the data of known analogues. Four sesquiterpenoids (1, 4, 5, and 6) and all the diterpenoids (8–15) were evaluated for inhibition of nitric oxide production in lipopolysaccharides (LPS)-activated RAW 264.7 macrophages and the results showed that compounds 10 and 15 exhibited moderate inhibitory activities against nitric oxide production. MDPI 2016-04-13 /pmc/articles/PMC6273599/ /pubmed/27089309 http://dx.doi.org/10.3390/molecules21040490 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chang, Chi-I
Chen, Chien-Chih
Chao, Che-Yi
Wang, Sheng-Yang
Chang, Hsun-Shuo
Sung, Ping-Jyun
Huang, Guan-Jhong
Li, Yen-Cheng
Kuo, Yueh-Hsiung
Sesquiterpenoids and Diterpenoids from the Wood of Cunninghamia konishii and Their Inhibitory Activities against NO Production
title Sesquiterpenoids and Diterpenoids from the Wood of Cunninghamia konishii and Their Inhibitory Activities against NO Production
title_full Sesquiterpenoids and Diterpenoids from the Wood of Cunninghamia konishii and Their Inhibitory Activities against NO Production
title_fullStr Sesquiterpenoids and Diterpenoids from the Wood of Cunninghamia konishii and Their Inhibitory Activities against NO Production
title_full_unstemmed Sesquiterpenoids and Diterpenoids from the Wood of Cunninghamia konishii and Their Inhibitory Activities against NO Production
title_short Sesquiterpenoids and Diterpenoids from the Wood of Cunninghamia konishii and Their Inhibitory Activities against NO Production
title_sort sesquiterpenoids and diterpenoids from the wood of cunninghamia konishii and their inhibitory activities against no production
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273599/
https://www.ncbi.nlm.nih.gov/pubmed/27089309
http://dx.doi.org/10.3390/molecules21040490
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