Cargando…

Synthesis and the Biological Activity of Phosphonylated 1,2,3-Triazolenaphthalimide Conjugates

A novel series of diethyl {4-[(5-substituted-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-methyl]-1H-1,2,3-triazol-1-yl}alkylphosphonates designed as analogues of amonafide was synthesized. All phosphonates were assessed for antiviral activity against a broad range of DNA and RNA viruses and several...

Descripción completa

Detalles Bibliográficos
Autores principales:	Głowacka, Iwona E., Gulej, Rafał, Grzonkowski, Piotr, Andrei, Graciela, Schols, Dominique, Snoeck, Robert, Piotrowska, Dorota G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273621/ https://www.ncbi.nlm.nih.gov/pubmed/27792200 http://dx.doi.org/10.3390/molecules21111420

Ejemplares similares

Phosphonylated Acyclic Guanosine Analogues with the 1,2,3-Triazole Linker
por: Głowacka, Iwona E., et al.
Publicado: (2015)

Design, synthesis, antiviral and cytostatic activity of ω-(1H-1,2,3-triazol-1-yl)(polyhydroxy)alkylphosphonates as acyclic nucleotide analogues
por: Głowacka, Iwona E., et al.
Publicado: (2014)

Design, Synthesis, Anti-Varicella-Zoster and Antimicrobial Activity of (Isoxazolidin-3-yl)Phosphonate Conjugates of N1-Functionalised Quinazoline-2,4-Diones
por: Łysakowska, Magdalena, et al.
Publicado: (2022)

New Isoxazolidine-Conjugates of Quinazolinones—Synthesis, Antiviral and Cytostatic Activity
por: Piotrowska, Dorota G., et al.
Publicado: (2016)

Synthesis, antiviral, cytotoxic and cytostatic evaluation of N(1)-(phosphonoalkyl)uracil derivatives
por: Rygielska-Tokarska, Dorota, et al.
Publicado: (2016)

Isoxazolidine Conjugates of N3-Substituted 6-Bromoquinazolinones—Synthesis, Anti-Varizella-Zoster Virus, and Anti-Cytomegalovirus Activity
por: Grabkowska-Drużyc, Magdalena, et al.
Publicado: (2018)

Novel Isoxazolidine and γ-Lactam Analogues of Homonucleosides
por: Piotrowska, Dorota G., et al.
Publicado: (2019)

Acyclic nucleoside phosphonates containing the amide bond
por: Głowacka, Iwona E., et al.
Publicado: (2016)

Acyclic nucleoside phosphonates containing the amide bond: hydroxy derivatives
por: Głowacka, Iwona E., et al.
Publicado: (2019)

Synthesis, anti-varicella-zoster virus and anti-cytomegalovirus activity of quinazoline-2,4-diones containing isoxazolidine and phosphonate substructures
por: Piotrowska, Dorota G., et al.
Publicado: (2017)

Novel N-Substituted 3-Aryl-4-(diethoxyphosphoryl)azetidin-2-ones as Antibiotic Enhancers and Antiviral Agents in Search for a Successful Treatment of Complex Infections
por: Głowacka, Iwona E., et al.
Publicado: (2021)

Design, Synthesis, and Antiviral Activity of Novel Ribonucleosides of 1,2,3‐Triazolylbenzyl‐aminophosphonates
por: Ouahrouch, Abdelaaziz, et al.
Publicado: (2015)

A new method for the synthesis of α-aminoalkylidenebisphosphonates and their asymmetric phosphonyl-phosphinyl and phosphonyl-phosphinoyl analogues
por: Kuźnik, Anna, et al.
Publicado: (2015)

Synthesis of Enantiomerically Pure N-Boc-Protected 1,2,3-Triaminopropylphosphonates and 1,2-Diamino-3-Hydroxypropylphosphonates
por: Trocha, Aleksandra, et al.
Publicado: (2019)

Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker
por: Piotrowska, Dorota G., et al.
Publicado: (2012)

Synthesis and Antioxidant Properties of Novel 1,2,3-Triazole-Containing Nitrones
por: Hadjipavlou-Litina, Dimitra, et al.
Publicado: (2022)

Design, antiviral and cytostatic properties of isoxazolidine-containing amonafide analogues
por: Kokosza, Kamil, et al.
Publicado: (2015)

Chemoselective Activation of Diethyl Phosphonates: Modular Synthesis of Biologically Relevant Phosphonylated Scaffolds
por: Adler, Pauline, et al.
Publicado: (2018)

Expedient synthesis and biological evaluation of alkenyl acyclic nucleoside phosphonate prodrugs
por: Pileggi, Elisa, et al.
Publicado: (2018)

Nucleobase-Derived Nitrones: Synthesis and Antioxidant and Neuroprotective Activities in an In Vitro Model of Ischemia–Reperfusion
por: Chamorro, Beatriz, et al.
Publicado: (2022)

Novel isoxazolidine analogues of homonucleosides and homonucleotides
por: Piotrowska, Dorota G., et al.
Publicado: (2016)

Synthesis of 3(2)-phosphonylated thiazolo[3,2-a]oxopyrimidines
por: Kaskevich, Ksenia I, et al.
Publicado: (2020)

N-(1-Phenylethyl)aziridine-2-carboxylate esters in the synthesis of biologically relevant compounds
por: Głowacka, Iwona E, et al.
Publicado: (2019)

Asymmetric Reactions of N-Phosphonyl/Phosphoryl Imines
por: Ray, Devalina, et al.
Publicado: (2023)

Synthesis of Enantiomerically Enriched Protected 2-Amino-, 2,3-Diamino- and 2-Amino-3-Hydroxypropylphosphonates
por: Trocha, Aleksandra, et al.
Publicado: (2023)

Synthesis of Functionalized Diethyl(pyrrolidin-2-yl)phosphonate and Diethyl(5-oxopyrrolidin-2-yl)phosphonate
por: Głowacka, Iwona E., et al.
Publicado: (2021)

Synthesis of nonracemic hydroxyglutamic acids
por: Piotrowska, Dorota G, et al.
Publicado: (2019)

Synthesis of Four Enantiomers of (1-Amino-3-Hydroxypropane-1,3-Diyl)Diphosphonic Acid as Diphosphonate Analogues of 4-Hydroxyglutamic Acid
por: Lebelt, Liwia, et al.
Publicado: (2022)

Antitumor and antiviral activities of 4-substituted 1,2,3-triazolyl-2,3-dibenzyl-L-ascorbic acid derivatives
por: Macan, Andrijana Meščić, et al.
Publicado: (2019)

One-Pot Phosphonylation of Heteroaromatic Lithium Reagents: The Scope and Limitations of Its Use for the Synthesis of Heteroaromatic Phosphonates
por: Chmielewska, Ewa, et al.
Publicado: (2023)

Addition and Cycloaddition Reactions of Phosphinyl- and Phosphonyl-2H-Azirines, Nitrosoalkenes and Azoalkenes
por: Lemos, Américo
Publicado: (2009)

Convergent Deboronative and Decarboxylative Phosphonylation Enabled by the Phosphite Radical Trap “BecaP”
por: Pagire, Santosh K., et al.
Publicado: (2023)

Synthesis and Evaluations of “1,4‐Triazolyl Combretacoumarins” and Desmethoxy Analogs
por: Khandaker, Tashrique A., et al.
Publicado: (2019)

The synthesis, antiviral, cytostatic and cytotoxic evaluation of a new series of acyclonucleotide analogues with a 1,2,3-triazole linker
por: Głowacka, Iwona E., et al.
Publicado: (2013)

Synthesis of a 3′-C-ethynyl-β-d-ribofuranose purine nucleoside library: Discovery of C7-deazapurine analogs as potent antiproliferative nucleosides
por: Hulpia, Fabian, et al.
Publicado: (2018)

Base Mediated Tandem Vinylogous Addition and Cyclization of γ-Phosphonyl/Sulfonyl Crotonates and Ynones: Synthesis of Functionalized 2-Pyrones
por: Parameshwar, Matam, et al.
Publicado: (2019)

Lignosulfonic acid exhibits broad-spectrum anti-HIV and anti-HSV activity and has potential for microbicidal applications
por: Férir, Geoffrey, et al.
Publicado: (2014)

How Is Acetylcholinesterase Phosphonylated by Soman? An Ab Initio QM/MM Molecular Dynamics Study
por: Sirin, Gulseher Sarah, et al.
Publicado: (2014)

Selective Phosphonylation of 5′-Adenosine Monophosphate (5′-AMP) via Pyrophosphite [PPi(III)]
por: Kaye, Karl, et al.
Publicado: (2016)

Retrospective detection for V-type OPNAs exposure via phosphonylation and disulfide adducts in albumin
por: Wang, Jin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_g4mp9jdanqrbe67chhlherle4d